芳香化酶抑制剂在改善卵巢刺激对不孕症治疗结局的有害影响中的作用。
The role of aromatase inhibitors in ameliorating deleterious effects of ovarian stimulation on outcome of infertility treatment.
作者信息
Mitwally Mohamed F M, Casper Robert F, Diamond Michael P
机构信息
Division of Reproductive Endocrinology & Infertility, Department of Obstetrics & Gynecology, Wayne State University, Detroit, Michigan, USA.
出版信息
Reprod Biol Endocrinol. 2005 Oct 4;3:54. doi: 10.1186/1477-7827-3-54.
Clinical utilization of ovulation stimulation to facilitate the ability of a couple to conceive has not only provided a valuable therapeutic approach, but has also yielded extensive information on the physiology of ovarian follicular recruitment, endometrial receptivity and early embryo competency. One of the consequences of the use of fertility enhancing agents for ovarian stimulation has been the creation of a hyperestrogenic state, which may influence each of these parameters. Use of aromatase inhibitors reduces hyperestrogenism inevitably attained during ovarian stimulation. In addition, the adjunct use of aromatase inhibitors during ovarian stimulation reduces amount of gonadotropins required for optimum stimulation. The unique approach of reducing hyperestrogenism, as well as lowering amount of gonadotropins without affecting the number of mature ovarian follicles is an exciting strategy that could result in improvement in the treatment outcome by ameliorating the deleterious effects of the ovarian stimulation on follicular development, endometrial receptivity, as well as oocyte and embryo quality.
使用排卵刺激来促进夫妇受孕的临床应用不仅提供了一种有价值的治疗方法，还产生了关于卵巢卵泡募集生理、子宫内膜容受性和早期胚胎能力的大量信息。使用促生育药物进行卵巢刺激的后果之一是产生了高雌激素状态，这可能会影响上述每一个参数。芳香化酶抑制剂的使用可减少卵巢刺激过程中不可避免出现的高雌激素血症。此外，在卵巢刺激过程中辅助使用芳香化酶抑制剂可减少达到最佳刺激所需的促性腺激素量。减少高雌激素血症以及在不影响成熟卵泡数量的情况下降低促性腺激素量的独特方法是一种令人兴奋的策略，通过改善卵巢刺激对卵泡发育、子宫内膜容受性以及卵母细胞和胚胎质量的有害影响，可能会改善治疗效果。
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