Department of Orthopaedic Medical Engineering, Osaka University Graduate School of Medicine, Osaka, Japan.
Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
Mod Rheumatol. 2022 Aug 20;32(5):1006-1012. doi: 10.1093/mr/roab065.
Osteonecrosis of the femoral head (ONFH) is a designated intractable disease (DID) in Japan. The Ministry of Health, Labour, and Welfare launched an online registry system for DIDs. We aimed to investigate the epidemiological characteristics of patients with ONFH using the DID database.
Data of patients with ONFH registered in the DID database between January 2004 and December 2013 were extracted. The incidence of new cases and distributions of sex, age, and associated risk factors were investigated. The prevalence of the two categories, 'steroid-associated' and 'alcohol-associated' risk factors, was estimated for each prefecture.
New 15,049 cases of ONFH were investigated. The mean registration rate-corrected annual ONFH incidence per 100,000 individuals was 1.77. The male-to-female ratio was 1.33. Age distribution peaked in the 40s and 50s for male and 60s for female. The prevalence of steroid-associated ONFH was lower in males (28.6%) than in females (49.8%), while that of alcohol-associated ONFH was higher in males (47.2%) than in females (9.3%). No clear region was identified for the steroids. The incidence of alcohol-associated ONFH was significantly higher in Tokyo and Okinawa, regardless of sex.
Alcohol-associated ONFH incidence varies geographically across Japan, suggesting that it has regional characteristics.
股骨头坏死（ONFH）是日本指定的难治性疾病（DID）。厚生劳动省启动了 DID 在线登记系统。我们旨在使用 DID 数据库研究 ONFH 患者的流行病学特征。
从 DID 数据库中提取 2004 年 1 月至 2013 年 12 月登记的 ONFH 患者数据。调查新发病例的发病率以及性别、年龄和相关危险因素的分布情况。估计每个县的“激素相关”和“酒精相关”两种危险因素的患病率。
共调查了 15,049 例新的 ONFH 病例。校正注册率后的年平均 ONFH 发病率为每 100,000 人 1.77 例。男女比例为 1.33。年龄分布在男性中以 40 多岁和 50 多岁为高峰，在女性中以 60 多岁为高峰。男性中激素相关 ONFH 的患病率（28.6%）低于女性（49.8%），而男性中酒精相关 ONFH 的患病率（47.2%）高于女性（9.3%）。在男性和女性中，类固醇的分布都没有明显的区域特征。无论性别如何，东京和冲绳的酒精相关性 ONFH 发病率均显著升高。
日本各地的酒精相关性 ONFH 发病率存在差异，表明其具有地域特征。
