日本人群中非创伤性股骨头坏死的发病率。
Incidence of nontraumatic osteonecrosis of the femoral head in the Japanese population.
作者信息
Yamaguchi Ryosuke, Yamamoto Takuaki, Motomura Goro, Ikemura Satoshi, Iwamoto Yukihide
机构信息
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
出版信息
Arthritis Rheum. 2011 Oct;63(10):3169-73. doi: 10.1002/art.30484.
OBJECTIVE
To estimate the incidence rate of nontraumatic osteonecrosis of the femoral head (ONFH) in the Japanese population.
METHODS
A survey was conducted to ascertain newly identified patients with nontraumatic ONFH in the Specified Disease Treatment Research Program of Fukuoka Prefecture (population 5 million) between 1999 and 2008. Distributions of age and sex in this population were investigated. Crude incidence rates of nontraumatic ONFH were calculated, and age-adjusted incidence rates were estimated by adjusting the crude values against those for the Japanese standard population in each year.
RESULTS
In Fukuoka Prefecture, 1,244 newly identified patients with nontraumatic ONFH were recruited into the Japanese subsidy program over the span of 10 years. The ratio of men to women was 1.6, comprising 758 men (61%; mean age 48 years) and 486 women (39%; mean age 56 years). The crude incidence rate of nontraumatic ONFH in the 10-year period was 2.58 cases per 100,000 person-years (range 1.54-3.66). The mean age-adjusted incidence rate was 2.51 cases per 100,000 person-years.
CONCLUSION
This study showed that the incidence rate of nontraumatic ONFH was 2.51 cases per 100,000 person-years in the Japanese population.
目的
估算日本人群中非创伤性股骨头坏死（ONFH）的发病率。
方法
在一项调查中，确定了1999年至2008年间福冈县特定疾病治疗研究项目（人口500万）中新确诊的非创伤性ONFH患者。调查了该人群的年龄和性别分布。计算非创伤性ONFH的粗发病率，并通过将每年的粗值与日本标准人群的粗值进行调整来估算年龄调整发病率。
结果
在福冈县，10年间有1244名新确诊的非创伤性ONFH患者被纳入日本补贴项目。男女比例为1.6，其中男性758人（61%；平均年龄48岁），女性486人（39%；平均年龄56岁）。10年期间非创伤性ONFH的粗发病率为每10万人年2.58例（范围1.54 - 3.66）。平均年龄调整发病率为每10万人年2.51例。
结论
本研究表明，日本人群中非创伤性ONFH的发病率为每10万人年2.51例。
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