Schroeder T, Vorstrup S, Lassen N A, Engell H C
J Cereb Blood Flow Metab. 1986 Dec;6(6):739-46. doi: 10.1038/jcbfm.1986.130.
Repeated bedside measurements of CBF have been made possible by the recent development of a mobile unit with 10 stationary detectors using the intravenous xenon-133 method. To evaluate this technique, comparative CBF studies at rest and following the application of a cerebral vasodilatory stimulus (acetazolamide, 1 g i.v.) were performed with the mobile equipment and with xenon-133 single-photon emission inhalation tomography in patients with cerebrovascular disease. The CBF level and the flow response to acetazolamide as determined with the two methods were well correlated, although at low flow levels the stationary detectors yielded somewhat lower CBF values than did emission tomography. Considering the side-to-side asymmetry, an excellent correlation was obtained. Using the initial slope index, the stationary detectors revealed quantitatively 83% of the interhemispheric asymmetry and 63% of the asymmetry in the middle cerebral artery territory shown with the tomograph. As illustrated by a case history, the nontomographic CBF unit used in this study may provide reliable and useful information in patients with occlusive cerebrovascular disease by performing repeated CBF studies and challenging the cerebral circulation with acetazolamide.
最近研制出一种带有10个固定探测器的移动装置，采用静脉注射氙-133法，使得能够在床边重复测量脑血流量（CBF）。为了评估该技术，使用该移动设备以及氙-133单光子发射吸入断层扫描技术，对脑血管疾病患者在静息状态下以及应用脑血管扩张刺激剂（乙酰唑胺，静脉注射1g）后进行了CBF对比研究。尽管在低流量水平时，固定探测器得出的CBF值略低于发射断层扫描得出的值，但两种方法测定的CBF水平以及对乙酰唑胺的血流反应具有良好的相关性。考虑到左右不对称性，两者具有极佳的相关性。使用初始斜率指数，固定探测器定量显示出半球间不对称性的83%以及断层扫描所示大脑中动脉区域不对称性的63%。正如一个病例所示，本研究中使用的非断层CBF装置通过重复进行CBF研究并使用乙酰唑胺刺激脑循环，可为患有闭塞性脑血管疾病的患者提供可靠且有用的信息。
