血管免疫母细胞性淋巴结病中单克隆T淋巴细胞增殖的证据。
Evidence for monoclonal T lymphocyte proliferation in angioimmunoblastic lymphadenopathy.
作者信息
O'Connor N T, Crick J A, Wainscoat J S, Gatter K C, Stein H, Falini B, Mason D Y
出版信息
J Clin Pathol. 1986 Nov;39(11):1229-32. doi: 10.1136/jcp.39.11.1229.
Abstract
The arrangement of the T cell receptor and immunoglobulin genes was analysed in lymphoid tissue biopsy specimens from 25 cases of angioimmunoblastic lymphadenopathy. Nineteen cases showed a rearrangement of the gene coding for the beta chain of the T cell receptor, and in one case a clonal rearrangement of immunoglobulin genes was shown (in which the T cell receptor gene was in a germline configuration). These findings indicate that a monoclonal T cell proliferation is present in most cases of angioimmunoblastic lymphadenopathy, and they also correlate with the fact that some patients who present with this disorder subsequently develop a T cell lymphoma.
摘要
对25例血管免疫母细胞性淋巴结病患者的淋巴组织活检标本进行了T细胞受体和免疫球蛋白基因的排列分析。19例显示T细胞受体β链编码基因发生重排，1例显示免疫球蛋白基因的克隆性重排（其中T细胞受体基因为种系构型）。这些发现表明，大多数血管免疫母细胞性淋巴结病患者存在单克隆T细胞增殖，这也与一些患有这种疾病的患者随后发展为T细胞淋巴瘤这一事实相关。
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