Jain Surabhi, Mallick Saumyaranjan, Ramteke Prashant, Gogia Ajay
Department of Pathology, Dr. B. R. A. Institute Rotary Cancer Hospital (Dr. B.R.A.I.R.C.H.), All India Institute of Medical Sciences (AIIMS) New Delhi, India.
Department of Medical Oncology, Dr. B. R. A. Institute Rotary Cancer Hospital (Dr. B.R.A.I.R.C.H.), All India Institute of Medical Sciences (AIIMS) New Delhi, India.
Am J Blood Res. 2022 Jun 20;12(3):64-81. eCollection 2022.
T-follicular helper cells (TFH) are a unique subset of T-cells with varied transcriptional profiles and functions. In the last 2016 WHO classification, lymphomas arising from TFH were included as a broad category and emphasis was given to separating them from other peripheral T cell lymphomas. The neoplasms derived from these mainly comprise angioimmunoblastic T-cell lymphoma, peripheral T-cell lymphoma with T-follicular helper cell phenotype, follicular T-cell lymphoma, and cutaneous CD4+ small-medium sized lymphoproliferative disorders. The TFH lymphomas comprise both indolent and aggressive forms. Additional immunohistochemistry to identify TFH cells like CD10, BCL6, ICOS, PD1, CXCL13 and mutations like RHOA, IDH2 is required for diagnosis and prognostication. The understanding of these has evolved over the years, and currently we review the updates and pathobiology of the above.
T滤泡辅助细胞（TFH）是一类独特的T细胞亚群，具有多样的转录谱和功能。在2016年世界卫生组织的最新分类中，源自TFH的淋巴瘤被归为一个宽泛的类别，并着重强调将它们与其他外周T细胞淋巴瘤区分开来。源自这些细胞的肿瘤主要包括血管免疫母细胞性T细胞淋巴瘤、具有T滤泡辅助细胞表型的外周T细胞淋巴瘤、滤泡性T细胞淋巴瘤以及皮肤CD4+中小型淋巴增殖性疾病。TFH淋巴瘤包括惰性和侵袭性两种类型。诊断和预后评估需要额外的免疫组织化学检测来识别TFH细胞，如CD10、BCL6、ICOS、PD1、CXCL13以及RHOA、IDH2等基因突变。多年来，对这些的认识不断发展，目前我们对上述内容的更新和病理生物学进行综述。
