Bowman C A, Nelson R A
Laryngoscope. 1987 Jan;97(1):7-9. doi: 10.1288/00005537-198701000-00003.
Susceptibility to many autoimmune diseases is associated with inheritance of certain Human Leukocytic Antigens (HLA), determinants which have become diagnostic or prognostic markers. In this study of HLA antigen frequencies among patients with autoimmune sensorineural hearing loss, 39 patients with this otologic disorder were typed for HLA-A, B, C, and DR antigens. A significant increase of Cw7 occurred in 51% of patients compared to 21% of 627 matched controls (relative risk, 3.95). Trends towards increased frequencies of Cw4, B35 and reduced frequency of DR4 were also observed. These data suggest a possible immunogenetic predisposition to this otologic disorder. The presence of Cw7 may facilitate the diagnosis of autoimmune sensorineural hearing loss.
许多自身免疫性疾病的易感性与某些人类白细胞抗原（HLA）的遗传相关，这些决定因素已成为诊断或预后标志物。在这项针对自身免疫性感音神经性听力损失患者的HLA抗原频率研究中，对39例患有这种耳科疾病的患者进行了HLA - A、B、C和DR抗原分型。与627名匹配对照中的21%相比，51%的患者中Cw7显著增加（相对风险为3.95）。还观察到Cw4、B35频率增加以及DR4频率降低的趋势。这些数据表明这种耳科疾病可能存在免疫遗传易感性。Cw7的存在可能有助于自身免疫性感音神经性听力损失的诊断。
