不良童年经历、血清素能系统与成年人的抑郁和焦虑障碍：系统文献综述。
Adverse childhood experiences, the serotonergic system, and depressive and anxiety disorders in adulthood: A systematic literature review.
机构信息
University of Pennsylvania, School of Nursing, Family and Community Health, 418 Curie Blvd., Philadelphia, PA, 19104, United States; National Clinician Scholars Program at Duke University, 200 Morris Street, Suite 3400, DUMC Box 104427, Durham, NC, 27701, United States.
University of Pennsylvania, School of Nursing, Family and Community Health, 418 Curie Blvd., Philadelphia, PA, 19104, United States.
出版信息
Neurosci Biobehav Rev. 2022 Mar;134:104495. doi: 10.1016/j.neubiorev.2021.12.018. Epub 2021 Dec 15.
BACKGROUND
Recent studies have examined the role that the serotonergic system plays in moderating the association between adverse childhood experiences (ACEs) and depressive and anxiety disorders in adulthood. The aim of this literature review is to synthesize studies that examined serotonin's impact in relation to ACEs, and depressive and anxiety disorders in this population.
METHODS
Published studies from 2008 to 2018 were retrieved from PubMed, CINAHL, and PsychINFO databases, and were included if ACEs, the serotonergic system, and depressive and or anxiety disorders were assessed in those with a mean age between nineteen and forty.
RESULTS
Twenty-eight studies were included. Various genetic polymorphisms in the serotonergic signaling system moderated the association between ACEs and depression. Additionally, selective serotonin reuptake inhibitors with a high affinity for the serotonin transporter, resulted in poor treatment outcomes for those with history of ACEs.
CONCLUSION
Additional research is needed in order to further define the role that the serotonergic genes play in the association between ACEs and depressive and anxiety disorders in adulthood.
背景
最近的研究探讨了 5-羟色胺能系统在调节童年逆境（ACEs）与成年人抑郁和焦虑障碍之间关联中的作用。本文献综述的目的是综合研究 5-羟色胺在 ACEs 与该人群中抑郁和焦虑障碍之间的影响。
方法
从 PubMed、CINAHL 和 PsychINFO 数据库中检索到 2008 年至 2018 年发表的研究，纳入标准为 ACEs、5-羟色胺能系统以及抑郁和/或焦虑障碍在平均年龄为 19 至 40 岁之间的人群中进行评估。
结果
共纳入 28 项研究。5-羟色胺信号系统中的各种基因多态性调节了 ACEs 与抑郁之间的关联。此外，对 5-羟色胺转运体具有高亲和力的选择性 5-羟色胺再摄取抑制剂，导致有 ACEs 病史的患者治疗效果不佳。
结论
需要进一步的研究来进一步确定 5-羟色胺基因在 ACEs 与成年人抑郁和焦虑障碍之间关联中的作用。
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