Bai Yu, Shu Chang, Hou Ying, Wang Gao-Hua
Department of Psychiatry, Renmin Hospital of Wuhan University, Institute of Neuropsychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Peking University China-Japan Friendship School of Clinical Medicine, Department of Neurology, Beijing, China.
Front Psychiatry. 2024 Apr 2;15:1309022. doi: 10.3389/fpsyt.2024.1309022. eCollection 2024.
Depression is the most common psychiatric disorder that burdens modern society heavily. Numerous studies have shown that adverse childhood experiences can increase susceptibility to depression, and depression with adverse childhood experiences has specific clinical-biological features. However, the specific neurobiological mechanisms are not yet precise. Recent studies suggest that the gut microbiota can influence brain function and behavior associated with depression through the "microbe-gut-brain axis" and that the composition and function of the gut microbiota are influenced by early stress. These studies offer a possibility that gut microbiota mediates the relationship between adverse childhood experiences and depression. However, few studies directly link adverse childhood experiences, gut microbiota, and depression. This article reviews recent studies on the relationship among adverse childhood experiences, gut microbiota, and depression, intending to provide insights for new research.
抑郁症是困扰现代社会的最常见精神疾病。大量研究表明，童年不良经历会增加患抑郁症的易感性，且伴有童年不良经历的抑郁症具有特定的临床生物学特征。然而，具体的神经生物学机制尚不清楚。近期研究表明，肠道微生物群可通过“微生物-肠道-脑轴”影响与抑郁症相关的脑功能和行为，且肠道微生物群的组成和功能受早期应激的影响。这些研究为肠道微生物群介导童年不良经历与抑郁症之间的关系提供了一种可能性。然而，很少有研究直接将童年不良经历、肠道微生物群和抑郁症联系起来。本文综述了近期关于童年不良经历、肠道微生物群和抑郁症之间关系的研究，旨在为新的研究提供思路。
