Friskopp J, Engström P E, Sundqvist K G
Scand J Dent Res. 1986 Oct;94(5):443-7. doi: 10.1111/j.1600-0722.1986.tb01785.x.
Gingival biopsies from five patients with cyclosporin A (CsA) induced enlargement of the gingiva contained prominent mononuclear infiltrates beneath the epithelial basement membrane. These infiltrates and surrounding tissues were studied using monoclonal antibodies directed against lymphocytes and their subgroups (OKT 3, OKT 4, OKT 8, Leu 3 and Leu 4), monocytes (OKM 1) and the framework structure of HLA-DR antigens (OKI al). As revealed by the reactivity of these antibodies the vast majority of the mononuclear cells in two individuals consisted of monocytes and in the others of T-lymphocytes. Virtually no B-lymphocytes were observed. The ratio between T-cells bearing T 4 and T 8 antigens, in separate biopsies, varied between 6 and 0.3. Control biopsies were obtained from the gingiva of seven healthy individuals without gingivitis. These biopsies contained relatively few mononuclear cells all of which had T-lymphocyte phenotype.
对五名因环孢素A（CsA）导致牙龈增生的患者进行牙龈活检，发现上皮基底膜下方有明显的单核细胞浸润。使用针对淋巴细胞及其亚群（OKT 3、OKT 4、OKT 8、Leu 3和Leu 4）、单核细胞（OKM 1）以及HLA-DR抗原框架结构（OKI al）的单克隆抗体对这些浸润细胞和周围组织进行研究。这些抗体的反应显示，两名患者中绝大多数单核细胞为单核细胞，其他患者中则为T淋巴细胞。几乎未观察到B淋巴细胞。在单独的活检中，携带T 4和T 8抗原的T细胞比例在6至0.3之间变化。对照活检取自七名无牙龈炎的健康个体的牙龈。这些活检组织中的单核细胞相对较少，且均具有T淋巴细胞表型。
