2015 年版日本基础系列斑贴试验：4 年经验。

Patch testing with the Japanese baseline series 2015: A 4-year experience.

机构信息

Department of Dermatology, Nagata Clinic, Niigata, Japan.

Japanese Contact Dermatitis Research Group, Nagoya, Japan.

出版信息

Contact Dermatitis. 2022 Mar;86(3):189-195. doi: 10.1111/cod.14027. Epub 2022 Jan 4.

DOI:10.1111/cod.14027

PMID:34921568

Abstract

BACKGROUND

The Japanese baseline series (JBS), established in 1994, was updated in 2008 and 2015. The JBS 2015 is a modification of the thin-layer rapid-use epicutaneous (TRUE) test (SmartPractice Denmark, Hillerød, Denmark). No nationwide studies concerning the TRUE test have previously been reported.

OBJECTIVES

To determine the prevalence of sensitizations to JBS 2015 allergens from 2015 to 2018.

METHODS

We investigated JBS 2015 patch test results using the web-registered Skin Safety Care Information Network (SSCI-Net) from April 2015 to March 2019.

RESULTS

Patch test results of 5865 patients were registered from 63 facilities. The five allergens with the highest positivity rates were gold sodium thiosulfate (GST; 25.7%), nickel sulfate (24.5%), urushiol (9.1%), p-phenylenediamine (PPD; 8.9%), and cobalt chloride (8.4%). The five allergens with the lowest positivity rates were mercaptobenzothiazole (0.8%), formaldehyde (0.9%), paraben mix (1.1%), mercapto mix (1.1%), and PPD black rubber mix (1.4%).

CONCLUSIONS

Nickel sulfate and GST had the highest positivity rates. The JBS 2015, including a modified TRUE test, is suitable for baseline series patch testing.

摘要

背景

日本基线系列（JBS）于 1994 年建立，并于 2008 年和 2015 年进行了更新。JBS 2015 是对薄层快速经皮（TRUE）试验（丹麦 SmartPractice，希勒勒）的修改。此前，尚未有关于 TRUE 试验的全国性研究报告。

目的

确定 2015 年至 2018 年 JBS 2015 变应原致敏的流行率。

方法

我们使用在线注册的皮肤安全护理信息网络（SSCI-Net）调查了 2015 年 4 月至 2019 年 3 月期间的 JBS 2015 斑贴试验结果。

结果

来自 63 个机构的 5865 名患者的斑贴试验结果被注册。阳性率最高的五种变应原是硫代硫酸钠金（GST；25.7%）、硫酸镍（24.5%）、漆酚（9.1%）、对苯二胺（PPD；8.9%）和氯化钴（8.4%）。阳性率最低的五种变应原是巯基苯并噻唑（0.8%）、甲醛（0.9%）、对羟基苯甲酸酯混合物（1.1%）、巯基混合物（1.1%）和 PPD 黑色橡胶混合物（1.4%）。