镍、铬和钴的定位对斑贴试验结果的干扰。
Interference of the positioning of nickel, chromium and cobalt in the results of patch tests.
作者信息
Duarte Ida, Lazzarini Rosana, Haffner Mariana, Silva Julia P
机构信息
Department of Medicine, Faculty of Medical Sciences, Santa Casa de São Paulo, São Paulo, SP, Brazil.
Department of Medicine, Dermatology Clinic, Santa Casa de São Paulo, São Paulo, SP, Brazil.
出版信息
An Bras Dermatol. 2025 Mar-Apr;100(2):272-276. doi: 10.1016/j.abd.2024.03.016. Epub 2024 Dec 10.
BACKGROUND
The positioning of substances, which are co-sensitizers and/or with a tendency to cross-react, is not considered in the technique when applying patch tests (PT).
OBJECTIVE
To investigate the interference of the positioning of nickel (Ni), chromium (Cr) and cobalt (Co) in patch tests (PT) results, when applied close or distant from each other.
METHODS
PT were performed in patients suspected of allergic contact dermatitis (ACD), using the standard battery (SB), with substances showing a tendency towards cross-react and co-sensitizers applied far apart, and an additional battery (AB) with the metals placed close to each other. For tabulation purposes, only the 96-h reading was considered.
RESULTS
Of the 86 tested patients, 33 (38%) had negative testing for metals and 53 (62%) had one or more positive (+) tests for Ni, Cr and/or Co. Concordant results in both tests (SB/ AB) occurred in 18/53 (34%) and 35/53 (66%) had discordant results. Regarding the SB, of the 159 tests with metals (53 patients, three metals), 57 tests were (+) and 102 (-). In the AB, 87 tests were (+) and 72 (-), a statistically significant difference (p < 0.05). Of the 57 (+) tests in the SB, 35 were for Ni, 18 for Co and four for Cr. In AB the number of (+) tests was 87, with 45 (+) tests for Ni, 35 for Co and seven for Cr. The difference in the number of positive tests between the two batteries was statistically significant for Co and Ni.
STUDY LIMITATIONS
The number of cases.
CONCLUSION
The results showed that the positioning of the metals interferes with the PT results and should be considered as part of the PT application technique.
背景
在进行斑贴试验（PT）时，该技术未考虑共致敏剂和/或有交叉反应倾向的物质的放置位置。
目的
研究镍（Ni）、铬（Cr）和钴（Co）在斑贴试验（PT）中彼此靠近或远离放置时对试验结果的干扰。
方法
对疑似过敏性接触性皮炎（ACD）的患者进行PT，使用标准组合（SB），将有交叉反应倾向的物质和共致敏剂放置得相距很远，另外使用一个附加组合（AB），将金属放置得彼此靠近。为了制表，仅考虑96小时的读数。
结果
在86名受试患者中，33名（38%）金属检测为阴性，53名（62%）对Ni、Cr和/或Co有一项或多项阳性（+）检测结果。两项试验（SB/AB）结果一致的有18/53（34%），35/53（66%）结果不一致。关于SB，在159次金属检测（53名患者，三种金属）中，57次检测为（+），102次为（-）。在AB中，87次检测为（+），72次为（-），差异有统计学意义（p<0.05）。在SB的57次（+）检测中，35次针对Ni，18次针对Co，4次针对Cr。在AB中，（+）检测次数为87次，其中45次针对Ni，35次针对Co，7次针对Cr。两个组合之间阳性检测次数的差异对Co和Ni有统计学意义。
研究局限性
病例数量。
结论
结果表明金属的放置位置会干扰PT结果，应将其视为PT应用技术的一部分。
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