Department of Neuroscience, Washington University School of Medicine, 660 S Euclid Ave, Box 8108, St Louis, MO 63110, USA.
Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA.
Neuroimage. 2022 Feb 15;247:118728. doi: 10.1016/j.neuroimage.2021.118728. Epub 2021 Dec 16.
Resting-state functional MRI (rsfMRI) provides a view of human brain organization based on correlation patterns of blood oxygen level dependent (BOLD) signals recorded across the whole brain. The neural basis of resting-state BOLD fluctuations and their correlation remains poorly understood. We simultaneously recorded oxygen level, spikes, and local field potential (LFP) at multiple sites in awake, resting monkeys. Following a spike, the average local oxygen and LFP voltage responses each resemble a task-driven BOLD response, with LFP preceding oxygen by 0.5 s. Between sites, features of the long-range correlation patterns of oxygen, LFP, and spikes are similar to features seen in rsfMRI. Most of the variance shared between sites lies in the infraslow frequency band (0.01-0.1 Hz) and in the infraslow envelope of higher-frequency bands (e.g. gamma LFP). While gamma LFP and infraslow LFP are both strong correlates of local oxygen, infraslow LFP explains significantly more of the variance shared between correlated oxygen signals than any other electrophysiological signal. Together these findings are consistent with a causal relationship between infraslow LFP and long-range oxygen correlations in the resting state.
静息态功能磁共振成像（rsfMRI）提供了一种基于全脑血氧水平依赖（BOLD）信号相关模式来观察人脑组织的方法。静息态 BOLD 波动及其相关性的神经基础仍知之甚少。我们在清醒、休息的猴子中同时记录了多个部位的氧水平、尖峰和局部场电位（LFP）。在尖峰之后，平均局部氧和 LFP 电压响应都类似于任务驱动的 BOLD 响应，LFP 比氧提前 0.5 秒。在不同部位之间，氧、LFP 和尖峰的长程相关模式的特征与 rsfMRI 中观察到的特征相似。大多数部位之间共享的方差位于亚慢频率带（0.01-0.1 Hz）和较高频率带的亚慢包络（例如，γ LFP）中。虽然 γ LFP 和亚慢 LFP 都是局部氧的强相关信号，但亚慢 LFP 解释了相关氧信号之间共享的方差，比任何其他电生理信号都多。这些发现都一致表明，在静息状态下，亚慢 LFP 与长程氧相关性之间存在因果关系。
