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肠杆菌胶囊口服治疗后伴焦虑和抑郁的肠易激综合征患者肠道菌群的动态变化。

Dynamic changes of intestinal flora in patients with irritable bowel syndrome combined with anxiety and depression after oral administration of enterobacteria capsules.

机构信息

Department of Intensive Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.

Shengli Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, China.

出版信息

Bioengineered. 2021 Dec;12(2):11885-11897. doi: 10.1080/21655979.2021.1999374.

DOI:10.1080/21655979.2021.1999374
PMID:34923901
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8810103/
Abstract

This study investigated the clinical characteristics and dynamic changes of intestinal bacterial community to evaluate the curative effect of fecal microbiota transplantation (FMT) on irritable bowel syndrome with predominant diarrhea (IBS-D) comorbid with anxiety and depression. Total two treatments were designed in randomize-controlled trial includes oral FMT capsules with 1 week (A1), 8 weeks (A2), and 12 weeks (A3), as well as oral empty capsules with 1 week (B1), 8 weeks (B2), and 12 weeks (B3) as control for comparison. The positive therapeutic effects occurred in FMT colonized patient with IBS-D comorbid psychological disorder, demonstrated at alleviated IBS-D severity (IBS-SSS score from 291.11 reduced to 144.44), altered stool type (from 6 changed to 4), reduced anxiety and depression scores (from 18.33 to 8.39 and from 22.33 to 17.78) after FMT-treated 12 weeks. The FMT therapy improved bacterial alpha diversity and the majority bacterial community predominant by and , and the relative abundance (RA) was higher after FMT-treated 12 weeks (50.61% and 45.52%) than control (47.62% and 38.96%). In short, FMT therapy has great potential for IBS-D patients combined with anxiety and depression by alleviated clinical symptoms and restore the intestinal micro-ecology.

摘要

本研究旨在通过评估粪便微生物群移植（FMT）对伴有焦虑和抑郁的腹泻型肠易激综合征（IBS-D）的临床疗效，探讨肠道细菌群落的临床特征和动态变化。在随机对照试验中设计了两种治疗方法，包括口服 FMT 胶囊 1 周（A1）、8 周（A2）和 12 周（A3），以及口服空胶囊 1 周（B1）、8 周（B2）和 12 周（B3）作为对照进行比较。FMT 定植于伴有心理障碍的 IBS-D 患者后，出现了积极的治疗效果，表现为 IBS-D 严重程度减轻（IBS-SSS 评分从 291.11 降至 144.44）、粪便类型改变（从 6 种变为 4 种）、焦虑和抑郁评分降低（从 18.33 降至 8.39 和从 22.33 降至 17.78）。FMT 治疗 12 周后，改善了细菌 α 多样性和主要细菌群落，以 和 为主，相对丰度（RA）也高于对照组（50.61%和 45.52%）（47.62%和 38.96%）。总之，FMT 治疗通过缓解临床症状和恢复肠道微生态，对伴有焦虑和抑郁的 IBS-D 患者具有很大的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e85/8810103/cbde56e68223/KBIE_A_1999374_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e85/8810103/9a727b6ccb83/KBIE_A_1999374_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e85/8810103/aadbd4696d9d/KBIE_A_1999374_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e85/8810103/5fe73b0e8e11/KBIE_A_1999374_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e85/8810103/6d92be35416a/KBIE_A_1999374_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e85/8810103/8c1962505072/KBIE_A_1999374_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e85/8810103/cbde56e68223/KBIE_A_1999374_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e85/8810103/9a727b6ccb83/KBIE_A_1999374_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e85/8810103/aadbd4696d9d/KBIE_A_1999374_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e85/8810103/5fe73b0e8e11/KBIE_A_1999374_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e85/8810103/6d92be35416a/KBIE_A_1999374_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e85/8810103/8c1962505072/KBIE_A_1999374_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e85/8810103/cbde56e68223/KBIE_A_1999374_F0005_OC.jpg

相似文献

[1]
Dynamic changes of intestinal flora in patients with irritable bowel syndrome combined with anxiety and depression after oral administration of enterobacteria capsules.

Bioengineered. 2021-12

[2]
The multiple effects of fecal microbiota transplantation on diarrhea-predominant irritable bowel syndrome (IBS-D) patients with anxiety and depression behaviors.

Microb Cell Fact. 2021-12-28

[3]
Faecal microbiota transplantation for diarrhoea-predominant irritable bowel syndrome: a double-blind, randomised, placebo-controlled trial.

Lancet Gastroenterol Hepatol. 2019-7-17

[4]
Relief of irritable bowel syndrome by fecal microbiota transplantation is associated with changes in diversity and composition of the gut microbiota.

J Dig Dis. 2019-7-7

[5]
The effect of fecal microbiota transplantation on psychiatric symptoms among patients with irritable bowel syndrome, functional diarrhea and functional constipation: An open-label observational study.

J Affect Disord. 2018-4-12

[6]
Engraftment of strictly anaerobic oxygen-sensitive bacteria in irritable bowel syndrome patients following fecal microbiota transplantation does not improve symptoms.

Gut Microbes. 2021

[7]
The kinetics of gut microbial community composition in patients with irritable bowel syndrome following fecal microbiota transplantation.

PLoS One. 2018-11-14

[8]
Bifidobacterium-Rich Fecal Donor May Be a Positive Predictor for Successful Fecal Microbiota Transplantation in Patients with Irritable Bowel Syndrome.

Digestion. 2017

[9]
Clinical response to fecal microbiota transplantation in patients with diarrhea-predominant irritable bowel syndrome is associated with normalization of fecal microbiota composition and short-chain fatty acid levels.

Scand J Gastroenterol. 2019-6

[10]
Faecal microbiota transplantation alters gut microbiota in patients with irritable bowel syndrome: results from a randomised, double-blind placebo-controlled study.

Gut. 2018-7-6

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[2]
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World J Psychiatry. 2025-8-19

[3]
Fecal Microbiota Transplantation for Disorders of Gut-Brain Interaction: Current Insights, Effectiveness, and Future Perspectives.

Curr Gastroenterol Rep. 2025-7-9

[4]
Gut Microbiota: A New Challenge in Mood Disorder Research.

Life (Basel). 2025-4-3

[5]
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Front Med (Lausanne). 2025-3-14

[6]
Energy metabolism and the intestinal barrier: implications for understanding and managing intestinal diseases.

Front Microbiol. 2025-1-31

[7]
Gut microbial dysbiosis associated to diarrheic irritable bowel syndrome can be efficiently simulated in the Mucosal ARtificial COLon (M-ARCOL).

Bioengineered. 2025-12

[8]
Anxiety disorders and the gut microbiota: a bibliometric and visual analysis.

Front Psychiatry. 2025-1-20

[9]
Role of the gut microbiome in psychological symptoms associated with inflammatory bowel diseases.

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[10]
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本文引用的文献

[1]
Changes in the gut microbiome and metabolome in a rat model of pulmonary arterial hypertension.

Bioengineered. 2021-12

[2]
Glucagon-like peptide (GLP) -2 improved colonizing bacteria and reduced severity of ulcerative colitis by enhancing the diversity and abundance of intestinal mucosa.

Bioengineered. 2021-12

[3]
Profile of gut microbiota in patients with traumatic thoracic spinal cord injury and its clinical implications: a case-control study in a rehabilitation setting.

Bioengineered. 2021-12

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The relationship between gut microbiota and proteolytic activity in irritable bowel syndrome.

Microb Pathog. 2021-8

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The roles of microbial products in the development of colorectal cancer: a review.

Bioengineered. 2021-12

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Genome-wide study of key genes and scoring system as potential noninvasive biomarkers for detection of suicide behavior in major depression disorder.

Bioengineered. 2020-12

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Fecal Microbiota Transplantation for multidrug-resistant organism: Efficacy and Response prediction.

J Infect. 2020-11

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Recent advances in diagnosis and management of irritable bowel syndrome.

Curr Opin Psychiatry. 2020-9

[9]
Fecal transplants as a microbiome-based therapeutic.

Curr Opin Microbiol. 2020-8

[10]
Autologous fecal microbiota transplantation for the treatment of inflammatory bowel disease.

Transl Res. 2020-12

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