Marano Giuseppe, Rossi Sara, Sfratta Greta, Traversi Gianandrea, Lisci Francesco Maria, Anesini Maria Benedetta, Pola Roberto, Gasbarrini Antonio, Gaetani Eleonora, Mazza Marianna
Unit of Psychiatry, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Department of Neurosciences, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Life (Basel). 2025 Apr 3;15(4):593. doi: 10.3390/life15040593.
The gut microbiome has emerged as a novel and intriguing focus in mood disorder research. Emerging evidence demonstrates the significant role of the gut microbiome in influencing mental health, suggesting a bidirectional communication between the gut and the brain. This review examines the latest findings on the gut-microbiota-brain axis and elucidates how alterations in gut microbiota composition can influence this axis, leading to changes in brain function and behavior. Although dietary interventions, prebiotics, probiotics, and fecal microbiota transplantation have yielded encouraging results, significant advances are needed to establish next-generation approaches that precisely target the neurobiological mechanisms of mood disorders. Future research must focus on developing personalized treatments, facilitated by innovative therapies and technological progress, which account for individual variables such as age, sex, drug history, and lifestyle. Highlighting the potential therapeutic implications of targeting the gut microbiota, this review emphasizes the importance of integrating microbiota research into psychiatric studies to develop more effective and personalized treatment strategies for mood disorders.
肠道微生物群已成为情绪障碍研究中一个新颖且引人关注的焦点。新出现的证据表明肠道微生物群在影响心理健康方面发挥着重要作用，这暗示了肠道与大脑之间存在双向交流。本综述探讨了关于肠道微生物群-脑轴的最新研究结果，并阐明了肠道微生物群组成的改变如何影响该轴，进而导致脑功能和行为的变化。尽管饮食干预、益生元、益生菌和粪便微生物群移植已取得了令人鼓舞的结果，但仍需要取得重大进展，以建立精确针对情绪障碍神经生物学机制的下一代方法。未来的研究必须专注于开发个性化治疗方案，借助创新疗法和技术进步，充分考虑年龄、性别、用药史和生活方式等个体变量。本综述强调了针对肠道微生物群的潜在治疗意义，强调了将微生物群研究纳入精神病学研究以开发更有效和个性化情绪障碍治疗策略的重要性。
