Huang Wenjie, Fan Li, Tang Yongmei, Chi Yinxiu, Li Jingjing
Department of Reproductive Medicine, Liuzhou Maternity and Child Healthcare Hospital, Affiliated Women and Children's Hospital of Guangxi University of Science and Technology, Liuzhou, Guangxi, 545001, People's Republic of China.
School of Basic Medicine, Central South University, Changsha, Hunan, 410078, People's Republic of China.
Int J Gen Med. 2021 Dec 11;14:9629-9645. doi: 10.2147/IJGM.S341076. eCollection 2021.
Integrin beta4 (ITGB4) is a transmembrane receptor that plays a key role in tumorigenesis and tumor development. However, there are no pan-cancer analyses of ITGB4.
This study demonstrates the first potential oncogenic roles of ITGB4 across 33 tumors based on the dataset of the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO).
ITGB4 is highly expressed in many cancers, and distinct correlations exist between ITGB4 expression and the prognosis of tumor patients. We also found that the methylation and genetic alteration level of ITGB4 was associated with some cancer prognosis. Furthermore, we found a reduced phosphorylation of ITGB4 at S1457 in several tumors, such as breast and ovarian cancers. Finally, ITGB4 expression was correlated with cancer-associated fibroblasts in liver hepatocellular carcinoma and prostate adenocarcinoma, and the infiltration level of NK cells and neutrophils was observed in other cancers, such as breast invasive carcinoma and lung adenocarcinoma. Moreover, RNA metabolism and protein processing-associated functions are involved in the functional mechanism of ITGB4.
Our first pan-cancer study may offer a relatively comprehensive understanding of the oncogenic roles of ITGB4 across different tumors.
整合素β4（ITGB4）是一种跨膜受体，在肿瘤发生和肿瘤发展中起关键作用。然而，目前尚无关于ITGB4的泛癌分析。
本研究基于癌症基因组图谱（TCGA）和基因表达综合数据库（GEO）的数据，首次展示了ITGB4在33种肿瘤中的潜在致癌作用。
ITGB4在多种癌症中高表达，且ITGB4表达与肿瘤患者预后存在显著相关性。我们还发现ITGB4的甲基化和基因改变水平与某些癌症的预后相关。此外，我们发现在一些肿瘤如乳腺癌和卵巢癌中，ITGB4在S1457位点的磷酸化水平降低。最后，在肝细胞癌和前列腺腺癌中，ITGB4表达与癌症相关成纤维细胞相关，在其他癌症如乳腺浸润性癌和肺腺癌中观察到自然杀伤细胞和中性粒细胞的浸润水平。此外，RNA代谢和蛋白质加工相关功能参与了ITGB4的功能机制。
我们的首次泛癌研究可能为全面了解ITGB4在不同肿瘤中的致癌作用提供帮助。
