Department of Organic Chemistry and Medicinal Chemistry, Pharmaceutical College, Guangxi Medical University, Nanning, People's Republic of China.
Guangxi Key Laboratory of Thalassemia Research, Life Sciences Institute, Guangxi Medical University, Nanning, People's Republic of China.
Cancer Biother Radiopharm. 2022 May;37(4):256-275. doi: 10.1089/cbr.2020.3943. Epub 2020 Nov 11.
The expression level and clinical significance of integrin subunit beta 4 () in head and neck squamous cell carcinoma (HNSCC) remain unclear. Expression of in HNSCC tissues was evaluated by calculating standard mean differences (SMDs) based on gene chips, RNA-seq, and immunohistochemistry data ( = 2330) from multiple sources. Receiver operating characteristic (ROC) curves were used to detect the ability of to distinguish HNSCC from non-HNSCC samples. The relationship between the expression level of and clinical parameters was evaluated by calculating SMDs. Identical results of mRNA and protein levels indicated remarkable up-expression of in HNSCC tissues. Further ROC curves showed that could distinguish HNSCC from non-HNSCC samples. Genetic alteration analysis of in HNSCC indicated that overexpression of in HNSCC was likely not owing to genetic alteration of . Moreover, overexpression level may be correlated with clinical T stage. likely plays an essential role in HNSCC occurrence based on our study and its potential diagnostic value is worthy of further exploration in the future.
整合素亚基β 4（）在头颈部鳞状细胞癌（HNSCC）中的表达水平和临床意义尚不清楚。通过计算来自多个来源的基因芯片、RNA-seq 和免疫组织化学数据（ = 2330）的标准均数差（SMD），评估了 在 HNSCC 组织中的表达。接收器操作特征（ROC）曲线用于检测区分 HNSCC 与非 HNSCC 样本的能力。通过计算 SMD 评估 表达水平与临床参数之间的关系。mRNA 和蛋白水平的相同结果表明 在 HNSCC 组织中显著上调。进一步的 ROC 曲线表明 可区分 HNSCC 与非 HNSCC 样本。HNSCC 中 的遗传改变分析表明， 在 HNSCC 中的过表达可能不是由于 的遗传改变。此外， 过表达水平可能与临床 T 分期相关。基于我们的研究， 可能在 HNSCC 的发生中发挥重要作用，其潜在的诊断价值值得未来进一步探索。
