Matsunaga Masahiro, Ohtsubo Yohsuke, Masuda Takahiko, Noguchi Yasuki, Yamasue Hidenori, Ishii Keiko
Department of Health and Psychosocial Medicine, Aichi Medical University School of Medicine, Nagakute, Japan.
Department of Social Psychology, Graduate School of Humanities and Sociology, The University of Tokyo, Bunkyō, Japan.
Front Behav Neurosci. 2021 Dec 2;15:774879. doi: 10.3389/fnbeh.2021.774879. eCollection 2021.
Previous studies in population genetics have proposed that the Y-chromosomal (Y-DNA) haplogroup D ancestor likely originated from Africa. The haplogroup D branch next started Out-of-Africa migration, rapidly expanded across Eurasia, and later diversified in East Asia. Y-DNA haplogroup D-M55, one of the branches of haplogroup D, is only found in modern Japanese males, suggesting that individuals with Y-DNA haplogroup D migrated from the Eurasian continent. Based on previous observations, Y-DNA haplogroup D is expected to be associated with some male characteristics including personality. Therefore, this study investigated whether the Y-DNA haplogroup D-M55 is associated with several physiological and psychological characteristics, including exploratory motivation and human relationship-related perception. We recruited Japanese young adult males and females and investigated the association between Y-DNA haplogroup D-M55, physiological [body mass index (BMI)], and several psychological parameters [perceived number of close friends, behavioral inhibition system/behavioral activation system (BIS/BAS), perceived happiness, and perceived loneliness]. The results indicated that males with haplogroup D-M55 had a higher BMI and more close friends, compared with non-carrier males. Additional multiple regression analyses, which tested the hypothesis that haplogroup D-M55 predicts BMI and perceived number of close friends, confirmed our hypothesis, even after controlling for the potentially confounding variables of age and sex. We also analyzed the gene-gene interaction between haplogroup D-M55 and an autosomal gene polymorphism associated with BMI and human relationships, such as the dopamine D2 receptor gene (: rs1800497). Results showed gene-gene interactions between haplogroups D-M55 and in BMI. Based on these findings, it is demonstrated that Y-DNA haplogroup D is associated with human personality.
以往群体遗传学研究提出，Y染色体（Y-DNA）单倍群D的祖先可能起源于非洲。单倍群D分支随后开始走出非洲迁移，迅速扩展至欧亚大陆，后来在东亚地区分化。Y-DNA单倍群D-M55是单倍群D的分支之一，仅在现代日本男性中发现，这表明Y-DNA单倍群D的个体是从欧亚大陆迁移而来。基于以往观察，预计Y-DNA单倍群D与包括性格在内的一些男性特征有关。因此，本研究调查了Y-DNA单倍群D-M55是否与包括探索动机和人际关系相关认知在内的多种生理和心理特征有关。我们招募了日本年轻成年男性和女性，调查了Y-DNA单倍群D-M55、生理指标[体重指数（BMI）]以及几个心理参数[亲密朋友的感知数量、行为抑制系统/行为激活系统（BIS/BAS）、感知幸福和感知孤独]之间的关联。结果表明，与非携带者男性相比，单倍群D-M55的男性BMI更高，亲密朋友更多。额外的多元回归分析检验了单倍群D-M55预测BMI和亲密朋友感知数量的假设，即使在控制了年龄和性别的潜在混杂变量后，也证实了我们的假设。我们还分析了单倍群D-M55与一个与BMI和人际关系相关的常染色体基因多态性（如多巴胺D2受体基因：rs1800497）之间的基因-基因相互作用。结果显示单倍群D-M55与BMI之间存在基因-基因相互作用。基于这些发现，证明了Y-DNA单倍群D与人类性格有关。
