Ding Wei, Li Xiaoyan, Ji Baojun, Wang Zhenna
Department of Ultrasound, People's Hospital of Rizhao, Rizhao 276800, China.
Department of Blood Transfusion, Weifang People's Hospital, Weifang 261041, China.
Evid Based Complement Alternat Med. 2021 Dec 9;2021:6881720. doi: 10.1155/2021/6881720. eCollection 2021.
Cervical cancer is a common malignant neoplasm in women, and its incidence is increasing year by year. This study explored the effects of traditional Chinese medicine combined with recombinant human interferon 2b in cervical cancer patients. 178 cervical intraepithelial neoplasias (CIN) combined with high-risk HPV-positive patients from June 2017 to August 2020 were divided into the study group ( = 89 cases) and the control group ( = 89 cases) by the random number table method. Patients in the control group were treated with recombinant human interferon 2b, and the study group was treated with traditional Chinese medicine (TCM) on the basis of the control group. After treatment, the recurrence rate in the study group was significantly decreased while the human papillomavirus (HPV) negative conversion rate was significantly increased. 3 months after treatment, the TCM symptom scores in the study group were lower than in the control group. Moreover, serum levels of inflammatory factors decreased in both groups, and the decrease was more significant in the study group. After treatment, the ultrasound parameters were significantly decreased in the study group than in the control group. In conclusion, traditional Chinese medicine combined with recombinant human interferon 2b in cervical cancer patients could effectively improve the negative conversion rate of HPV infection, the level of inflammatory factors, reduce the degree of cervical erosion, and enhance the immunity of patients with high safety and significantly improve the quality of life.
宫颈癌是女性常见的恶性肿瘤，其发病率逐年上升。本研究探讨了中药联合重组人干扰素2b对宫颈癌患者的影响。选取2017年6月至2020年8月的178例宫颈上皮内瘤变（CIN）合并高危HPV阳性患者，采用随机数字表法分为研究组（n = 89例）和对照组（n = 89例）。对照组患者采用重组人干扰素2b治疗，研究组在对照组治疗的基础上加用中药治疗。治疗后，研究组的复发率显著降低，而人乳头瘤病毒（HPV）转阴率显著提高。治疗3个月后，研究组的中医症状评分低于对照组。此外，两组患者血清炎症因子水平均降低，且研究组降低更显著。治疗后，研究组的超声参数较对照组显著降低。综上所述，中药联合重组人干扰素2b治疗宫颈癌患者可有效提高HPV感染转阴率、炎症因子水平，减轻宫颈糜烂程度，增强患者免疫力，安全性高，显著提高生活质量。
