Piciu A, Cainap C, Sur D, Havasi A, Fetica B, Balacescu O, Mester A, Cainap S
"Iuliu Hatieganu" University of Medicine and Pharmacy, Faculty of Medicine - Medical Oncology, Cluj-Napoca, Romania.
"Prof Dr Ion Chiricuta" Oncology Institute - Pathology and Molecular Biology, Cluj-Napoca, Romania.
Acta Endocrinol (Buchar). 2021 Apr-Jun;17(2):259-265. doi: 10.4183/aeb.2021.259.
Female adnexal tumors of probable Wolffian origin (FATWO) represent very rare borderline ovarian tumors with low malignant potential. Only 15 cases of malignant FATWO are described in the current literature, among which, only 5 are reported as being recurrent.
Due to the rare presentation of the recurrence of the malignant FATWO and the few cases reported in the scientific database, there are no clear therapy recommendations. This paper should help practitioners to choose the best therapy approach.
This paper presents the 6 case of malignant recurrent FATWO and will compare all the cases available in the literature.
We present a review of the literature comparing the therapeutic approaches and outcomes of all the five cases of recurrent malignant FATWOs. Also, we introduce the case of a stage III Wolffian origin adnexal tumor with multiple recurrences appeared after 6 years of disease free interval.
Our case presents the longest survival reported in the literature and underwent most surgical procedures of the recurrences and more than 4 lines of chemotherapy regimens.
This paper shows possible therapeutic approaches to be used as example by the practitioners according to the drug availability in their centers.
可能起源于沃尔夫管的女性附件肿瘤（FATWO）是非常罕见的低恶性潜能的交界性卵巢肿瘤。目前文献中仅描述了15例恶性FATWO，其中仅有5例报告有复发情况。
由于恶性FATWO复发情况罕见且科学数据库中报告的病例较少，目前尚无明确的治疗建议。本文旨在帮助从业者选择最佳治疗方法。
本文介绍了6例复发性恶性FATWO病例，并将对文献中所有可用病例进行比较。
我们对文献进行综述，比较所有5例复发性恶性FATWO的治疗方法和结果。此外，我们还介绍了1例III期起源于沃尔夫管的附件肿瘤病例，该病例在无病间隔6年后出现多次复发。
我们的病例是文献中报道生存时间最长的，经历了最多的复发手术和超过4线的化疗方案。
本文展示了一些可能的治疗方法，从业者可根据其所在中心的药物供应情况将其作为范例使用。
