Chi Cheng, Li Guoliang, Zheng Zian, Wang Xiangyu, Liu Xiangyu
Minjiang Road Community Health Service Center, Shinan District Medical Health Group, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Department of Radiation Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Front Oncol. 2025 Mar 18;15:1526030. doi: 10.3389/fonc.2025.1526030. eCollection 2025.
Wolffian adnexal tumor (WAT) is a rare neoplasm originating from the remnants of the Wolffian duct (mesonephric duct). Malignant WAT occurring in the ovary is exceptionally uncommon. This article presents a case of malignant WAT in the ovary, analyzing and discussing its histological features, diagnostic challenges, biological behavior, and treatment options in conjunction with relevant literature to enhance our understanding of this rare tumor.
A 64-year-old woman presented with an 8-month history of persistent abdominal pain and distension. An exploratory laparotomy revealed a small amount of pale-yellow ascites, a slightly atrophic uterus, and a left ovary without significant abnormalities. A solid mass measuring approximately 12 × 10 cm was observed between the left fallopian tube and ovary, displaying extensive dense adhesions to the posterior broad ligament and surrounding bowel. Frozen section pathology indicated a malignant tumor with necrotic areas suggestive of poorly differentiated carcinoma. The patient subsequently underwent a total hysterectomy, bilateral adnexectomy, omentectomy, pelvic lymphadenectomy, and pelvic adhesion release. Adjuvant chemotherapy with four cycles of paclitaxel and carboplatin (TC regimen) was administered, achieving normalization of tumor markers by the second cycle.
WAT is a rare entity within the spectrum of female reproductive system tumors, predominantly benign in nature. Due to its extremely low incidence, standardized treatment protocols remain elusive. Further research is warranted to establish effective management strategies and provide a reference for future cases.
沃尔夫管附件肿瘤（WAT）是一种起源于沃尔夫管（中肾管）残余的罕见肿瘤。发生在卵巢的恶性WAT极为罕见。本文报告一例卵巢恶性WAT病例，结合相关文献分析和讨论其组织学特征、诊断挑战、生物学行为及治疗选择，以增进我们对这种罕见肿瘤的认识。
一名64岁女性，有8个月持续性腹痛和腹胀病史。剖腹探查发现少量淡黄色腹水、子宫轻度萎缩，左侧卵巢无明显异常。在左侧输卵管和卵巢之间观察到一个大小约为12×10 cm的实性肿块，与阔韧带后叶及周围肠管有广泛致密粘连。冰冻切片病理显示为恶性肿瘤，有坏死区域，提示低分化癌。患者随后接受了全子宫切除术、双侧附件切除术、大网膜切除术、盆腔淋巴结清扫术及盆腔粘连松解术。给予四个周期的紫杉醇和卡铂辅助化疗（TC方案），第二个周期肿瘤标志物恢复正常。
WAT是女性生殖系统肿瘤中的罕见类型，本质上多为良性。由于其发病率极低，标准化治疗方案仍不明确。有必要进一步开展研究以制定有效的管理策略，并为未来病例提供参考。
