Kebe Bekalu, Getachew Melese, Molla Yalew, Bahiru Bereket, Dessie Bekalu
Clinical Pharmacy Unit, Department of Pharmacy, College of Health Science, Debre Markos University, Debre Markos, Ethiopia.
Pharmaceutics Unit, Department of Pharmacy, College of Health Science, Debre Markos University, Debre Markos, Ethiopia.
SAGE Open Med. 2021 Nov 23;9:20503121211057336. doi: 10.1177/20503121211057336. eCollection 2021.
Heart failure is a major public health problem worldwide. Since heart failure with reduced ejection fraction and preserved ejection fraction are different clinical entities, in-hospital mortality may occur at different rates. This study aimed to assess the management, survival, and predictors of mortality among hospitalized heart failure patients at Debre Markos comprehensive specialized medical ward.
A prospective cohort study was conducted on 228 heart failure patients at Debre Markos Comprehensive Specialized Hospital medical wards. A structured data collection tool was used to collect data. Data were analyzed using SPSS version 21.0. The Kaplan-Meier survival curve was used to investigate if there was a difference in the in-hospital survival between heart failure with a reduced ejection fraction and heart failure with a preserved ejection fraction. Those variables having -value < 0.05 were considered statistically significant.
From the 228 participants, 126 (55.3%) were females with a mean age of 53.32 ± 15.68 years. One hundred thirty-three (58.3%) patients were presented with preserved (⩾50%) level of ejection fraction. The all-cause in-hospital death rate was 12.7%, and the risk of in-hospital mortality was higher in heart failure patients with reduced ejection fraction (7.4% vs 5.3%; = 0.005). Current occupation ( = 0.041), elevated serum creatinine ( = 0.010), reduced ejection fraction ( = 0.017), and asthma/chronic obstructive pulmonary disease comorbidity ( = 0.002) were the independent predictors of high hospital mortality.
The rate of in-hospital mortality among heart failure patients was high. Healthcare providers should provide effective education activities and define disease management strategies for patients with reduced ejection fractions.
心力衰竭是全球主要的公共卫生问题。由于射血分数降低的心力衰竭和射血分数保留的心力衰竭是不同的临床实体，住院死亡率可能以不同的速率发生。本研究旨在评估德布雷马科斯综合专科医疗病房住院心力衰竭患者的管理、生存率和死亡预测因素。
对德布雷马科斯综合专科医院医疗病房的228例心力衰竭患者进行了一项前瞻性队列研究。使用结构化数据收集工具收集数据。数据使用SPSS 21.0版本进行分析。采用Kaplan-Meier生存曲线研究射血分数降低的心力衰竭和射血分数保留的心力衰竭患者在住院生存率上是否存在差异。那些P值<0.05的变量被认为具有统计学意义。
在228名参与者中，126名（55.3%）为女性，平均年龄为53.32±15.68岁。133名（58.3%）患者的射血分数水平保留（≥50%）。全因住院死亡率为12.7%，射血分数降低的心力衰竭患者的住院死亡风险更高（7.4%对5.3%；P=0.005）。当前职业（P=0.041）、血清肌酐升高（P=0.010）、射血分数降低（P=0.017）和哮喘/慢性阻塞性肺疾病合并症（P=0.002）是高住院死亡率的独立预测因素。
心力衰竭患者的住院死亡率较高。医疗服务提供者应为射血分数降低的患者提供有效的教育活动并制定疾病管理策略。
