Boutilier R G, Glass M L, Heisler N
J Exp Biol. 1986 Nov;126:33-9. doi: 10.1242/jeb.126.1.33.
The distribution of pulmocutaneous heart output to lungs and skin was determined in non-anaesthetized, fully recovered bullfrogs (Rana catesbeiana) by application of the microsphere method in order to study the modulation of blood flow to different gas exchange sites in amphibians during environmental air and water hypoxia. The relative perfusion of various skin areas was found to be rather heterogeneously distributed with an over-proportionately high blood flow to the ventral body surface. This distribution of flow among different skin areas remained unaffected by any type of environmental hypoxia. The relative perfusion of lungs and skin, however, was significantly affected by the pattern of environmental oxygen partial pressure. The relative lung perfusion (approximately equal to 80% of pulmocutaneous flow in normoxic control conditions) was increased during water hypoxia, and reduced with lowered inspired PO2. This mechanism could be interpreted as a readjustment of blood flow towards the gas exchange site with higher oxygen partial pressure, but may also represent a mechanism to prevent oxygen loss from the body stores at gas exchange sites of low oxygen tension.
为了研究两栖动物在环境空气和水体缺氧期间不同气体交换部位的血流调节，采用微球法测定了未麻醉、已完全恢复的牛蛙（牛蛙）肺皮心输出量在肺和皮肤之间的分布情况。研究发现，不同皮肤区域的相对灌注分布相当不均匀，腹侧体表的血流比例过高。不同皮肤区域之间的这种血流分布不受任何类型环境缺氧的影响。然而，肺和皮肤的相对灌注受到环境氧分压模式的显著影响。相对肺灌注（在常氧对照条件下约等于肺皮血流的80%）在水体缺氧期间增加，并随着吸入氧分压的降低而减少。这种机制可以解释为血流向氧分压较高的气体交换部位的重新调整，但也可能代表一种防止机体储存的氧气在低氧张力气体交换部位流失的机制。
