Vinh An Do T, Lan Anh Le, Tuan Tung Nguyen
Hematology and Blood Transfusion, Bach Mai Hospital, Hanoi, VNM.
Cureus. 2021 Dec 7;13(12):e20249. doi: 10.7759/cureus.20249. eCollection 2021 Dec.
T-cell large granular lymphocytic leukemia (T-LGL leukemia) is a rare, chronic lymphoproliferative disorder in the peripheral blood. This is characterized by peripheral blood and bone marrow (BM) lymphocytic infiltration with clonal large granular lymphocytes (LGLs). The neoplastic cells of this disease display a mature T-cell immunophenotype, with the majority of cases showing a CD4-/CD8+ T-cell, T-cell receptor (TCR) subset immunophenotype versus other permutations of those markers.
T细胞大颗粒淋巴细胞白血病（T-LGL白血病）是一种外周血中罕见的慢性淋巴细胞增殖性疾病。其特征为外周血和骨髓（BM）有淋巴细胞浸润，并伴有克隆性大颗粒淋巴细胞（LGL）。该疾病的肿瘤细胞表现出成熟的T细胞免疫表型，大多数病例显示为CD4-/CD8+ T细胞、T细胞受体（TCR）亚群免疫表型，而非那些标志物的其他排列组合。
