Department of Stomatology, Weifang People's Hospital, Weifang, 261000 Shandong Province, China.
Biomed Res Int. 2021 Dec 10;2021:8544914. doi: 10.1155/2021/8544914. eCollection 2021.
lncRNA and microRNA affect the occurrence and development of many diseases, so they are expected to become diagnostic or predictive indicators. But the relationship between lncRNA FGD5-AS1 and miR-130a and the prognosis of chronic periodontitis is still unclear. The purpose of this study is to explore the prognostic value of the two in chronic periodontitis.
This study set out to investigate the prognostic value of lncRNA FGD5-AS1 and miR-130a in chronic periodontitis.
Eighty-seven patients with chronic periodontitis who visited our hospital from March 2016 to August 2017 were collected as an observation group (OG), and 72 subjects with periodontal health who underwent physical examination at the same time were collected as a control group (CG). The FGD5-AS1 and miR-130a expression levels of subjects in the two groups were compared, and prognosis of 87 patients who were reviewed one year later was counted. The expression levels of patients with different prognoses were compared when they were admitted to our hospital. We drew the ROC curve and explored the prognostic value of FGD5-AS1 and miR-130a. The risk factors for adverse prognosis were analyzed through logistic regression.
FGD5-AS1 was lowly expressed in patients, while miR-130a was highly expressed. FGD5-AS1 and miR-130a had certain diagnostic and predictive value in chronic periodontitis and patient prognosis. The higher the periodontal pocket, the higher the attachment loss. Lower FGD5-AS1 and higher miR-130a levels were independent prognostic risk factors.
lncRNA FGD5-AS1 is lowly expressed in patients with chronic periodontitis, while miR-130a is highly expressed. Both of them have certain diagnostic and prognostic value in chronic periodontitis and may be potential diagnostic and prognostic indicators.
lncRNA 和 microRNA 影响许多疾病的发生和发展，因此它们有望成为诊断或预测指标。但 lncRNA FGD5-AS1 和 miR-130a 与慢性牙周炎的关系尚不清楚。本研究旨在探讨两者对慢性牙周炎的预后价值。
本研究旨在探讨 lncRNA FGD5-AS1 和 miR-130a 在慢性牙周炎中的预后价值。
收集 2016 年 3 月至 2017 年 8 月我院就诊的 87 例慢性牙周炎患者作为观察组（OG），同期体检牙周健康者 72 例作为对照组（CG）。比较两组受试者 FGD5-AS1 和 miR-130a 的表达水平，并对 87 例患者一年后进行随访。比较入院时不同预后患者的表达水平。绘制 ROC 曲线，探讨 FGD5-AS1 和 miR-130a 的预后价值。通过逻辑回归分析不良预后的危险因素。
患者 FGD5-AS1 低表达，miR-130a 高表达。FGD5-AS1 和 miR-130a 对慢性牙周炎和患者预后具有一定的诊断和预测价值。牙周袋越高，附着丧失越高。较低的 FGD5-AS1 和较高的 miR-130a 水平是独立的预后危险因素。
慢性牙周炎患者 FGD5-AS1 低表达，miR-130a 高表达。两者对慢性牙周炎均具有一定的诊断和预后价值，可能是潜在的诊断和预后指标。
