Department of Dental Public Health, School of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia.
Department of Periodontology, School of Dental Medicine, Tufts University, Boston, MA, USA.
Biomed Res Int. 2018 Nov 28;2018:4578782. doi: 10.1155/2018/4578782. eCollection 2018.
Case definitions and criteria of periodontal diseases are not yet consistent worldwide. This can affect the accuracy of any comparison made between two studies. This study determines which are the most common chronic periodontitis case definitions as well as confounding variables that have been reported worldwide in periodontal literature. A systematic assessment on periodontal disease classification and confounders was conducted using all publications in MEDLINE, EMBASE, SCOPUS, and Google Scholar between 1965 and October 2017. Screening of eligible studies and data extraction were conducted in duplicate and independently by two reviewers. The search protocol produced 4,218 articles. Out of these, 492 potentially relevant articles were selected for review. Only 351 studies fulfilled the selection criteria. Combination of probing depth and clinical attachment loss was the most common chronic periodontitis case definitions used (121, studies, 34.5%). CPI/CPITN was the most common classification used. Age was the most common confounder studied in periodontal research (303 studies, 86.3%), followed by gender (268 studies, 76.4%) and race (138 studies, 39.3%). Albumin and creatinine were the least common variables studied (1 or 2 studies each). Different case definitions affect the prevalence and treatment consequences of periodontitis. We need to standardize periodontitis case definitions worldwide to avoid difficulties in case diagnosis and prognosis. Further studies need to be done to assess the association between periodontitis and several potential confounders.
牙周病的定义和标准在全球范围内尚未统一。这可能会影响两个研究之间进行任何比较的准确性。本研究旨在确定牙周病文献中全球报道的最常见的慢性牙周炎病例定义以及混杂变量。通过对 1965 年至 2017 年 10 月间 MEDLINE、EMBASE、SCOPUS 和 Google Scholar 中的所有出版物进行系统评估，研究了牙周病分类和混杂因素。筛选合格研究和提取数据由两名审查员独立进行重复操作。搜索方案产生了 4218 篇文章。在这些文章中，有 492 篇可能相关的文章被选择进行审查。只有 351 项研究符合选择标准。探测深度和临床附着丧失的组合是最常用的慢性牙周炎病例定义（121 项研究，占 34.5%）。CPI/CPITN 是最常用的分类方法。年龄是牙周病研究中最常见的混杂因素（303 项研究，占 86.3%），其次是性别（268 项研究，占 76.4%）和种族（138 项研究，占 39.3%）。白蛋白和肌酐是研究最少的变量（各有 1 或 2 项研究）。不同的病例定义会影响牙周炎的流行和治疗后果。我们需要在全球范围内规范牙周炎的病例定义，以避免在病例诊断和预后方面出现困难。需要进一步研究评估牙周炎与几个潜在混杂因素之间的关系。
