Mariani A P, Neff N H, Hadjiconstantinou M
Neurosci Lett. 1986 Dec 12;72(2):221-6. doi: 10.1016/0304-3940(86)90084-4.
The compound 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a relatively selective neurotoxin that destroys dopamine (DA)-containing nigrostriatal neurons. We have now studied the effects of MPTP on retinal dopaminergic neurons. Acute treatment resulted in the accumulation of DA when evaluated by direct chemical analysis or histofluorescence. Chronic treatment resulted in a decrease of DA, an apparent loss of fluorescent cells, and a striking increase of lipofuscin in the retina. Thus, MPTP may be a useful drug for studying the dopaminergic neuronal system of retina and the possible link between neurons and the accumulation of lipofuscin.
化合物1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）是一种相对选择性的神经毒素，可破坏含多巴胺（DA）的黑质纹状体神经元。我们现在研究了MPTP对视网膜多巴胺能神经元的影响。通过直接化学分析或组织荧光评估，急性处理导致DA积累。慢性处理导致视网膜中DA减少、荧光细胞明显丧失以及脂褐素显著增加。因此，MPTP可能是一种用于研究视网膜多巴胺能神经元系统以及神经元与脂褐素积累之间可能联系的有用药物。
