Neural Circuit Development and Regeneration Research Group, Animal Physiology and Neurobiology Section, Department of Biology, KU Leuven, Leuven, Belgium.
Oxurion NV, Heverlee, Belgium.
Aging Cell. 2022 Jan;21(1):e13537. doi: 10.1111/acel.13537. Epub 2021 Dec 19.
As the mammalian central nervous system matures, its regenerative ability decreases, leading to incomplete or non-recovery from the neurodegenerative diseases and central nervous system insults that we are increasingly facing in our aging world population. Current neuroregenerative research is largely directed toward identifying the molecular and cellular players that underlie central nervous system repair, yet it repeatedly ignores the aging context in which many of these diseases appear. Using an optic nerve crush model in a novel biogerontology model, that is, the short-living African turquoise killifish, the impact of aging on injury-induced optic nerve repair was investigated. This work reveals an age-related decline in axonal regeneration in female killifish, with different phases of the repair process being affected depending on the age. Interestingly, as in mammals, both a reduced intrinsic growth potential and a non-supportive cellular environment seem to lie at the basis of this impairment. Overall, we introduce the killifish visual system and its age-dependent regenerative ability as a model to identify new targets for neurorepair in non-regenerating individuals, thereby also considering the effects of aging on neurorepair.
随着哺乳动物中枢神经系统的成熟，其再生能力下降，导致在我们日益老龄化的世界人口中，退行性疾病和中枢神经系统损伤无法完全或无法恢复。目前的神经再生研究主要致力于确定中枢神经系统修复的分子和细胞成分，但它反复忽略了这些疾病出现的老龄化背景。本研究使用一种新型生物老年学模型（即短寿命的非洲绿松石热鱼）中的视神经挤压模型，研究了衰老对损伤诱导的视神经修复的影响。这项工作揭示了雌性热鱼中与年龄相关的轴突再生下降，不同的修复阶段受年龄影响。有趣的是，与哺乳动物一样，内在生长潜力降低和非支持性细胞环境似乎是这种损伤的基础。总的来说，我们将热鱼视觉系统及其随年龄变化的再生能力引入模型中，以确定非再生个体神经修复的新靶点，从而也考虑到衰老对神经修复的影响。
