From the Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine.
Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
J Clin Psychopharmacol. 2022;42(1):71-74. doi: 10.1097/JCP.0000000000001501.
The risk of sudden cardiac death in patients receiving atypical antipsychotics may be related to QTc prolongation. The aim of this study was to investigate the risk factors for QTc prolongation to prevent QTc prolongation and guide clinical practice.
All electrocardiogram recordings of 913 schizophrenia patients who were receiving atypical antipsychotics were reviewed for prolonged QTc and associated conditions. Binary logistic regression analysis was used to investigate risk factors for QTc prolongation.
Logistic regression analysis demonstrated that sex (odds ratio [OR], 0.386; P = 0.010), age (OR, 1.047; P = 0.000), high-density lipoprotein (OR, 0.257; P = 0.014), and antipsychotics dose (OR, 1.040; P = 0.036) were significantly associated with QTc prolongation.
In patients with male sex, elder age, low high-density lipoprotein, or large antipsychotics dose, QTc should be monitored more frequently.
接受非典型抗精神病药物治疗的患者发生心脏性猝死的风险可能与 QTc 延长有关。本研究旨在探讨 QTc 延长的危险因素，以预防 QTc 延长并指导临床实践。
对 913 例接受非典型抗精神病药物治疗的精神分裂症患者的所有心电图记录进行了回顾性分析，以评估 QTc 延长及相关情况。采用二项逻辑回归分析探讨 QTc 延长的危险因素。
逻辑回归分析显示，性别（比值比[OR]，0.386；P = 0.010）、年龄（OR，1.047；P = 0.000）、高密度脂蛋白（OR，0.257；P = 0.014）和抗精神病药物剂量（OR，1.040；P = 0.036）与 QTc 延长显著相关。
对于男性、年龄较大、高密度脂蛋白较低或抗精神病药物剂量较大的患者，应更频繁地监测 QTc。
