QTc prolongation in patients with schizophrenia taking antipsychotics: Prevalence and risk factors.

BACKGROUND

QTc prolongation is one of the possible complications in patients with schizophrenia taking antipsychotics, which leads to malignant cardiac arrhythmia. No meta-analysis has been reported assessing the prevalence and correlated risk factors for QTc prolongation.

METHODS

This meta-analysis aimed to assess the evidence for the prevalence of QTc prolongation and correlated risk factors in patients with schizophrenia taking antipsychotics. Web of Science and PubMed were searched according to preset strategy. The quality of research was assessed by the Newcastle-Ottawa Scale (NOS).

RESULTS

In all, 15 studies covering 15,540 patients with schizophrenia taking antipsychotics were included. Meta-analysis showed that the prevalence of QTc prolongation in patients with schizophrenia taking antipsychotics was about 4.0% (95% confidence interval (CI): 3.0%-5.0%,  < 0.001). The prevalence was about 4.0% in Asia (95%CI: 3.0%-6.0%,  < 0.001), about 5.0% in Europe (95%CI: 2.0%-7.0%,  < 0.001), and about 2.0% in America (95%CI: 1.0%-3.0%,  < 0.001). Sensitivity analyses indicated the robustness of the result. Publication bias analysis reported a certain publication bias ( = 3.37,  = 0.012). Meta-regression suggested that female and elderly patients were clinically associated with a higher prevalence of QTc prolongation. According to included studies, smoking, comorbidity of cardiovascular disease, and abnormal levels of high-density lipoprotein/low-density lipoprotein might be related to QTc prolongation in patients with schizophrenia taking antipsychotics.

CONCLUSIONS

The prevalence of QTc prolongation in patients with schizophrenia taking antipsychotics was about 4.0%. Female and elderly patients were more likely to experience QTc prolongation. Close electrocardiogram monitoring was suggested in these at-risk populations.