Benny Paula, Ahn Hyeong Jun, Burlingame Janet, Lee Men-Jean, Miller Corrie, Chen John, Urschitz Johann
Department of Obstetrics, Gynecology, and Women's Health, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, United States of America.
Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, United States of America.
PLoS One. 2021 Dec 20;16(12):e0261137. doi: 10.1371/journal.pone.0261137. eCollection 2021.
Genome-wide association studies have shown an increased risk of type-2-diabetes (T2DM) in patients who carry single nucleotide polymorphisms in several genes. We investigated whether the same gene loci confer a risk for gestational diabetes mellitus (GDM) in women from Hawaii, and in particular, Pacific Islander and Filipino populations.
Blood was collected from 291 women with GDM and 734 matched non-diabetic controls (Pacific Islanders: 71 GDM, 197 non-diabetic controls; Filipinos: 162 GDM, 395 controls; Japanese: 58 GDM, 142 controls). Maternal DNA was used to genotype and show allele frequencies of 25 different SNPs mapped to 18 different loci.
After adjusting for age, BMI, parity and gravidity by multivariable logistic regression, several SNPs showed significant associations with GDM and were ethnicity specific. In particular, SNPs rs1113132 (EXT2), rs1111875 (HHEX), rs2237892 (KCNQ1), rs2237895 (KCNQ1), rs10830963 (MTNR1B) and rs13266634 (SLC30A8) showed significant associations with GDM in Filipinos. For Japanese, SNPs rs4402960 (IGFBP2) and rs2237892 (KCNQ1) were significantly associated with GDM. For Pacific Islanders, SNPs rs10830963 (MTNR1B) and rs13266634 (SLC30A8) showed significant associations with GDM. Individually, none of the SNPs showed a consistent association with GDM across all three investigated ethnicities.
Several SNPs associated with T2DM are found to confer increased risk for GDM in a multiethnic cohort in Hawaii.
全基因组关联研究表明，携带多个基因单核苷酸多态性的患者患2型糖尿病（T2DM）的风险增加。我们调查了相同的基因位点是否会增加夏威夷女性，特别是太平洋岛民和菲律宾人群患妊娠期糖尿病（GDM）的风险。
收集了291名GDM女性和734名匹配的非糖尿病对照者的血液（太平洋岛民：71名GDM患者，197名非糖尿病对照者；菲律宾人：162名GDM患者，395名对照者；日本人：58名GDM患者，142名对照者）。利用母亲的DNA对映射到18个不同位点的25种不同单核苷酸多态性进行基因分型并显示其等位基因频率。
通过多变量逻辑回归对年龄、体重指数、产次和妊娠次数进行校正后，几种单核苷酸多态性与GDM存在显著关联，且具有种族特异性。特别是，单核苷酸多态性rs1113132（EXT2）、rs1111875（HHEX）、rs2237892（KCNQ1）、rs2237895（KCNQ1）、rs10830963（MTNR1B）和rs13266634（SLC30A8）在菲律宾人中与GDM存在显著关联。对于日本人，单核苷酸多态性rs4402960（IGFBP2）和rs2237892（KCNQ1）与GDM显著相关。对于太平洋岛民，单核苷酸多态性rs10830963（MTNR1B）和rs13266634（SLC30A8）与GDM存在显著关联。单独来看，在所有三个被调查的种族中，没有一种单核苷酸多态性与GDM有一致的关联。
在夏威夷的一个多民族队列中，发现几种与T2DM相关的单核苷酸多态性会增加GDM的风险。
