Kellie S E, Attfield M D, Hankinson J L, Castellan R M
Am J Epidemiol. 1987 Mar;125(3):437-44. doi: 10.1093/oxfordjournals.aje.a114549.
To clarify the association between spirometry variability and respiratory morbidity and mortality, the authors analyzed data for miners examined in the first round of the National Coal Study, 1969-1971, and they compared groups of miners who failed with those who met each of two spirometry variability criteria: a 5% criterion recommended by the American Thoracic Society, and a 200 ml criterion used in prior research studies. Compared with miners who met the 5% criterion (the best two forced vital capacities must be within 5% or 100 ml of one another), the group that failed had a lower mean for forced expiratory volume in one second (FEV1), and odds ratios for cough, phlegm, wheeze, shortness of breath, and death of 1.75, 1.67, 1.76, 2.71, and 1.30, respectively. The findings for the 200 ml criterion (the best two FEV1s must be within 200 ml of one another) were somewhat different. The group that failed versus the group that met this criterion had a higher mean for FEV1, and odds ratios for cough, phlegm, wheeze, shortness of breath, and death of 1.13, 1.07, 1.15, 1.43, and 0.94, respectively. Although the findings differ for the two criteria, the findings demonstrate that increased spirometry variability is associated with poorer health.
为了阐明肺功能测定变异性与呼吸系统发病率和死亡率之间的关联，作者分析了1969 - 1971年第一轮全国煤炭研究中接受检查的矿工的数据，并将未达标准的矿工组与达到两种肺功能测定变异性标准的矿工组进行了比较：一种是美国胸科学会推荐的5%标准，另一种是先前研究中使用的200毫升标准。与达到5%标准（最佳的两次用力肺活量必须相差在5%以内或100毫升以内）的矿工相比，未达标准的组一秒用力呼气容积（FEV1）的平均值较低，咳嗽、咳痰、喘息、气短和死亡的比值比分别为1.75、1.67、1.76、2.71和1.30。200毫升标准（最佳的两次FEV1必须相差在200毫升以内）的结果有所不同。未达标准的组与达到该标准的组相比，FEV1的平均值较高，咳嗽、咳痰、喘息、气短和死亡的比值比分别为1.13、1.07、1.15、1.43和0.94。尽管两种标准的结果不同，但这些结果表明肺功能测定变异性增加与健康状况较差有关。
