Mura P, Piriou A, Tallineau C, Reiss D
Ann Biol Clin (Paris). 1986;44(5):505-10.
A systematic study of urinary Neopterin was carried out, gathering two thousand five hundred measurements, on a hospital population of patients supposedly affected by tumors and the concentrations obtained were compared to the usual values determined at the same time on patients apparently free from any disease. Malignant tumors appear to be associated with high concentration of urinary Neopterin and this increase seems well correlated with the severity of the disease. Benign tumors correspond, on the contrary, to an appreciably normal excretion of Neopterin. A clinic study of Neopterin elimination specifies, however, that each elevated value must be followed with other determinations in order to rule out the possibility of an eventual viral infection at the incubation stage. The authors think that this dosage could represent a mean of discovery of professional cancers in high risk populations as well as an element in the supervision of anti-neoplastic treatments.
对尿新蝶呤进行了一项系统研究，收集了2500份测量数据，对象是一家医院中疑似患有肿瘤的患者群体，并将所获得的浓度与同时在明显无任何疾病的患者身上测定的正常值进行比较。恶性肿瘤似乎与尿新蝶呤的高浓度有关，而且这种增加似乎与疾病的严重程度密切相关。相反，良性肿瘤对应的新蝶呤排泄明显正常。然而，一项关于新蝶呤排泄的临床研究表明，每个升高的值都必须进行其他测定，以排除在潜伏期最终发生病毒感染的可能性。作者认为，这种检测方法可以作为发现高危人群职业性癌症的一种手段，也是抗肿瘤治疗监测的一个要素。
