Department of Gastroenterology, Xin Hua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Gastroenterology, Xin Hua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China.
EBioMedicine. 2022 Jan;75:103768. doi: 10.1016/j.ebiom.2021.103768. Epub 2021 Dec 17.
Nonalcoholic fatty liver disease (NAFLD) is a worldwide leading cause of chronic liver disease, but we still lack ideal non-invasive tools for diagnosis and evaluation of nonalcoholic steatohepatitis (NASH) and related liver fibrosis in NAFLD population. Systemic immune dysregulations such as metabolic inflammation are believed to play central role in the development of NAFLD, signifying the hope of utilizing quantitative and phenotypic changes in peripheral immune cells among NAFLD patients as a diagnostic tool of NASH and fibrosis. In this review, we summarize the known changes in peripheral immune cells from NAFLD/NASH patients and their potential relationship with NAFLD and NASH progression. Potential challenges and possible solutions for further clinical translation are also discussed.
非酒精性脂肪性肝病（NAFLD）是全球范围内导致慢性肝病的主要原因，但我们仍然缺乏理想的非侵入性工具来诊断和评估非酒精性脂肪性肝炎（NASH）和 NAFLD 人群中的相关肝纤维化。全身性免疫失调，如代谢性炎症，被认为在 NAFLD 的发展中起核心作用，这表明有希望利用 NAFLD 患者外周免疫细胞的数量和表型变化作为 NASH 和纤维化的诊断工具。在这篇综述中，我们总结了 NAFLD/NASH 患者外周免疫细胞的已知变化及其与 NAFLD 和 NASH 进展的潜在关系。还讨论了进一步临床转化的潜在挑战和可能的解决方案。
