金黄色葡萄球菌外排泵和对莫匹罗星诱导后环丙沙星和洗必泰的耐受性。
Staphylococcus aureus Efflux Pumps and Tolerance to Ciprofloxacin and Chlorhexidine following Induction by Mupirocin.
机构信息
Infectious Diseases Division and Medical Services, Massachusetts General Hospitalgrid.32224.35, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Antimicrob Agents Chemother. 2022 Feb 15;66(2):e0184521. doi: 10.1128/AAC.01845-21. Epub 2021 Dec 20.
Abstract
Mupirocin induced expression of genes encoding efflux pumps NorA and MepA as well as a yellow fluorescent protein (YFP) fluorescence reporter of NorA. Mupirocin exposure also produced reduced susceptibility to pump substrates ciprofloxacin and chlorhexidine, a change that was dependent on intact and , respectively.
摘要
莫匹罗星诱导编码外排泵 NorA 和 MepA 的基因表达以及 NorA 的黄色荧光蛋白（YFP）荧光报告基因。莫匹罗星暴露还导致对泵底物环丙沙星和氯己定的敏感性降低，这种变化分别依赖于完整的 和 。
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