Department of Pharmacology and Toxicology, College of Human Medicine (C.E.R., Y.J., A.P.B., L.M.K., S.A.), Institute for Integrative Toxicology (C.E.R.), Cell and Molecular Biology Program (C.E.R.), Applied Immunology Center for Education and Research (C.E.R.), Department of Food Science and Human Nutrition (A.P.B.), and College of Osteopathic Medicine (L.M.K.), Michigan State University, East Lansing, Michigan
Department of Pharmacology and Toxicology, College of Human Medicine (C.E.R., Y.J., A.P.B., L.M.K., S.A.), Institute for Integrative Toxicology (C.E.R.), Cell and Molecular Biology Program (C.E.R.), Applied Immunology Center for Education and Research (C.E.R.), Department of Food Science and Human Nutrition (A.P.B.), and College of Osteopathic Medicine (L.M.K.), Michigan State University, East Lansing, Michigan.
Drug Metab Dispos. 2022 Apr;50(4):500-507. doi: 10.1124/dmd.121.000414. Epub 2021 Dec 20.
Nuclear factor erythroid-derived 2-like 2 (Nrf2) is a stress-activated transcription factor that is highly responsive to oxidative stress and electrophilic stimuli. Upon activation, Nrf2 upregulates a battery of cytoprotective genes meant to prevent cell death or damage. In many models of inflammation, Nrf2 protects against the immune response and decreases injury, including in the context of asthma and allergy. However, in some models of asthma and allergy, Nrf2 either does not play a role or can even exacerbate inflammation. In general, the reasons behind these discrepancies are not clear and the mechanisms by which Nrf2 modulates immune response are largely uncharacterized. The aim of this review is to highlight current literature assessing the role of Nrf2 in allergy and asthma to understand Nrf2 as a potential therapeutic target. SIGNIFICANCE STATEMENT: Nuclear factor erythroid-derived 2-like 2 (Nrf2) is an important immune mediator that modulates numerous immune cell types in various inflammatory diseases, including allergy and asthma. There is considerable interest in Nrf2 as a drug target in inflammation, which is complicated by the complex nature of Nrf2 in the immune system. This review focuses on the role of Nrf2 in asthma and allergy, including in regulating immune cell function and in detoxifying xenobiotics that exacerbate these diseases.
核因子红细胞 2 相关因子 2（Nrf2）是一种应激激活转录因子，对氧化应激和亲电刺激高度敏感。激活后，Nrf2 上调一系列细胞保护基因，旨在防止细胞死亡或损伤。在许多炎症模型中，Nrf2 可保护机体免受免疫反应的影响，并减少损伤，包括在哮喘和过敏的情况下。然而，在一些哮喘和过敏模型中，Nrf2 要么不起作用，要么甚至可以加重炎症。一般来说，这些差异的背后原因尚不清楚，Nrf2 调节免疫反应的机制在很大程度上仍未被阐明。本综述的目的是强调当前评估 Nrf2 在过敏和哮喘中作用的文献，以了解 Nrf2 作为潜在治疗靶点的作用。
核因子红细胞 2 相关因子 2（Nrf2）是一种重要的免疫介质，可调节各种炎症性疾病（包括过敏和哮喘）中的多种免疫细胞类型。Nrf2 作为炎症的药物靶点引起了极大的兴趣，但 Nrf2 在免疫系统中的复杂性质使情况变得复杂。本综述重点关注 Nrf2 在哮喘和过敏中的作用，包括调节免疫细胞功能以及解毒可加重这些疾病的外源性物质。
