Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, United States; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, United States.
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, United States; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, United States; Cell and Molecular Biology Program, Michigan State University, East Lansing, MI, United States.
Adv Pharmacol. 2021;91:61-110. doi: 10.1016/bs.apha.2020.10.003. Epub 2021 Apr 8.
Nrf2 is a cytoprotective transcription factor which is involved in ameliorating oxidative stress and toxic insults. Recently, an immunomodulatory role for Nrf2 has gained appreciation as it has been shown to protect cells and hosts alike in a variety of immune and inflammatory disorders. However, Nrf2 utilizes numerous distinct pathways to elicit its immunomodulatory effects. In this review, we summarize the literature discussing the roles of Nrf2 in autoimmunity and infectious diseases with a goal of understanding the potential to therapeutically target Nrf2.
Nrf2 是一种细胞保护性转录因子，参与改善氧化应激和毒性损伤。最近，Nrf2 的免疫调节作用受到了重视，因为它在多种免疫和炎症性疾病中表现出对细胞和宿主的保护作用。然而，Nrf2 通过多种不同的途径发挥其免疫调节作用。在这篇综述中，我们总结了讨论 Nrf2 在自身免疫和传染病中作用的文献，旨在了解靶向 Nrf2 进行治疗的潜力。
