Koga Y, Caccia N, Toyonaga B, Spolski R, Yanagi Y, Yoshikai Y, Mak T W
Eur J Immunol. 1986 Dec;16(12):1643-6. doi: 10.1002/eji.1830161229.
We report here the isolation of a human T cell-specific cDNA clone (YT16) that encodes a protein with extensive homology to a family of transformation and proliferation-related protein-tyrosine kinases (PTK). The message size of YT16 is 2.2 kb and it encodes a protein of 507 amino acids with a mol. mass of 57,136 Daltons. The deduced protein sequence has an overall homology of about 50% to the viral oncogene products of src and yes. Around the PTK catalytic domain, the homologies increase to 70-80% between the deduced protein sequence of YT16 and those of the PTK viral oncogenes. Of special interest is the extensive homology between the deduced protein sequence of YT16 and that of a recently reported murine B and T lymphocyte-specific PTK, lskT. It is possible that YT16 either encodes the human homologue of this murine gene, or a protein with similar function(s) in T cells.
我们在此报告一个人T细胞特异性cDNA克隆（YT16）的分离，该克隆编码一种与转化和增殖相关的蛋白酪氨酸激酶（PTK）家族具有广泛同源性的蛋白质。YT16的信使核糖核酸大小为2.2 kb，它编码一个由507个氨基酸组成的蛋白质，分子量为57,136道尔顿。推导的蛋白质序列与src和yes的病毒癌基因产物总体同源性约为50%。在PTK催化结构域周围，YT16推导的蛋白质序列与PTK病毒癌基因的序列之间的同源性增加到70 - 80%。特别有趣的是，YT16推导的蛋白质序列与最近报道的小鼠B和T淋巴细胞特异性PTK lskT的序列具有广泛同源性。YT16可能要么编码该小鼠基因的人类同源物，要么编码在T细胞中具有类似功能的蛋白质。
