上气道阻力综合征的生活质量。

Quality of life in upper airway resistance syndrome.

机构信息

Hypnos Instituto del Sueño, Clínica San Felipe, Lima, Perú.

Universidad Peruana Cayetano Heredia, Facultad de Medicina, Lima, Perú.

出版信息

J Clin Sleep Med. 2022 May 1;18(5):1263-1270. doi: 10.5664/jcsm.9838.

DOI:10.5664/jcsm.9838

PMID:34931609

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9059598/

Abstract

STUDY OBJECTIVES

To evaluate the health-related quality of life (HRQoL) in patients with upper airway respiratory syndrome (UARS) and obstructive sleep apnea (OSA) compared to the general population (GP) in Lima, Peru, and to explore the variables associated with differences in HRQoL in patients with UARS.

METHODS

This was a retrospective study of medical and polysomnography records from 2009-2014 in a referral sleep medicine center for patients aged 18-64 years. UARS was defined by polysomnography as follows: apnea-hypopnea index < 5 events/h, oxygen saturation ≥ 92%, respiratory effort-related arousal index ≥ 5. HRQoL was assessed using the 36-Item Short Form Survey (version 1) questionnaire validated in Peru. The GP HRQoL was obtained from a population-based survey. Linear and logistic regression analyses were conducted.

RESULTS

We reviewed 1,329 polysomnograms and selected 888. UARS and OSA were diagnosed in 93 and 795 participants, respectively. The GP cohort consisted of 641 participants. Total HRQoL mean scores (95% confidence interval) in patients with UARS, patients with OSA, and the GP were 67.4 (63.7-71.1), 66.9 (65.4-68.4), and 82.9 (81.6-84.3), respectively. Patients with UARS and patients with OSA had a 5.5 times (95% confidence interval, 3.3-9.2) and 6.2 times (95% confidence interval, 4.6-8.4) greater probability of having a low total HRQoL score compared to patients in the GP, respectively. In patients with UARS, muscle pain, use of psychotropic medication, obesity, and depression were negatively correlated with the total HRQoL score.

CONCLUSIONS

The impact of OSA and UARS on HRQoL is similar between disease groups and markedly worse when compared to the impact in the GP. In patients with UARS, the presence of muscle pain, obesity, female sex, depression, and use of psychotropic medication negatively impacted HRQoL.

CITATION

Vizcarra-Escobar D, Duque KR, Barbagelata-Agüero F, Vizcarra JA. Quality of life in upper airway resistance syndrome. 2022;18(5):1263-1270.

摘要

研究目的

评估秘鲁利马的上气道呼吸综合征（UARS）和阻塞性睡眠呼吸暂停（OSA）患者的健康相关生活质量（HRQoL）与一般人群（GP）相比的差异，并探讨与 UARS 患者 HRQoL 差异相关的变量。

方法

这是一项回顾性研究，分析了 2009 年至 2014 年期间在转诊睡眠医学中心的医疗和多导睡眠图记录，纳入年龄在 18-64 岁的患者。UARS 通过多导睡眠图定义为：呼吸暂停-低通气指数<5 次/小时，氧饱和度≥92%，呼吸努力相关觉醒指数≥5。使用在秘鲁验证的 36 项简短调查问卷评估 HRQoL。GP 的 HRQoL 从基于人群的调查中获得。进行线性和逻辑回归分析。

结果

我们回顾了 1329 份多导睡眠图，选择了 888 份。UARS 和 OSA 分别在 93 名和 795 名参与者中诊断，GP 队列由 641 名参与者组成。UARS 患者、OSA 患者和 GP 的总 HRQoL 平均得分（95%置信区间）分别为 67.4（63.7-71.1）、66.9（65.4-68.4）和 82.9（81.6-84.3）。与 GP 患者相比，UARS 患者和 OSA 患者的总 HRQoL 评分低的可能性分别高出 5.5 倍（95%置信区间，3.3-9.2）和 6.2 倍（95%置信区间，4.6-8.4）。在 UARS 患者中，肌肉疼痛、使用精神药物、肥胖和抑郁与总 HRQoL 评分呈负相关。