Gargiulo P, Di Mario U, Dotta F, Kennedy R, Guy K, Pachi A, Fallucca F
Eur J Obstet Gynecol Reprod Biol. 1986 Nov;23(3-4):127-35. doi: 10.1016/0028-2243(86)90140-1.
The phenotyping of T-cell subsets and T cells at different stages of activation was performed using a panel of monoclonal antibodies in samples from normal pregnant women at different stages of gestation and in the cord blood of neonates. The data obtained from pregnant women showed a slight decrease in the total number of T cells at the beginning of pregnancy, whereas there was a clear increase in 4F2-positive lymphocytes after a few months of gestation. No significant increase in Class II-positive lymphocytes was observed in normal pregnant women in comparison with adult healthy women. The data from neonates revealed a clear decrease of OKT3- and OKT4-positive cells and an increase of 4F2-positive cells in comparison with control subjects. These data indicate that alerted, but not fully activated, lymphocytes are present in the circulation of both the mother, after the first months of pregnancy, and the neonate. This finding reinforces the concept that during pregnancy there is an activation of certain immune components rather than a general depression of the immune system.
利用一组单克隆抗体，对处于不同妊娠阶段的正常孕妇样本及新生儿脐带血中的T细胞亚群和不同激活阶段的T细胞进行了表型分析。从孕妇获得的数据显示，妊娠初期T细胞总数略有下降，而妊娠几个月后4F2阳性淋巴细胞明显增加。与成年健康女性相比，正常孕妇中未观察到II类阳性淋巴细胞显著增加。与对照受试者相比，新生儿的数据显示OKT3和OKT4阳性细胞明显减少，4F2阳性细胞增加。这些数据表明，妊娠头几个月后，母亲和新生儿的循环系统中均存在处于警觉但未完全激活状态的淋巴细胞。这一发现强化了这样一种概念，即妊娠期间某些免疫成分被激活，而不是免疫系统普遍受到抑制。
