Fuller R W
J Clin Psychiatry. 1987 Mar;48 Suppl:5-11.
The ways in which pharmacologic intervention is possible in the synthesis, storage, release, inactivation, and actions of serotonin as a brain neurotransmitter are outlined, and the effects on serotonergic neuron function of the drugs used in the treatment of depression are discussed. Antidepressant drugs that inhibit monoamine oxidase increase brain concentrations of serotonin as well as other monoamines. Some tricyclic antidepressant drugs inhibit serotonin uptake along with norepinephrine uptake. There is some evidence that serotonin precursors and serotonin-releasing drugs can have antidepressant efficacy. Recently, selective inhibitors of serotonin uptake have been shown to be effective in the treatment of depression. Selective drugs for modulating serotonergic function will facilitate understanding of the role of serotonin and of specific subtypes of serotonin receptors in depression.
概述了作为脑内神经递质的5-羟色胺在合成、储存、释放、失活及作用过程中可能进行药物干预的方式，并讨论了用于治疗抑郁症的药物对5-羟色胺能神经元功能的影响。抑制单胺氧化酶的抗抑郁药物可增加脑内5-羟色胺以及其他单胺的浓度。一些三环类抗抑郁药物在抑制去甲肾上腺素摄取的同时也抑制5-羟色胺摄取。有证据表明5-羟色胺前体及5-羟色胺释放药物具有抗抑郁疗效。最近，已证明5-羟色胺摄取选择性抑制剂对抑郁症治疗有效。调节5-羟色胺能功能的选择性药物将有助于了解5-羟色胺及5-羟色胺受体特定亚型在抑郁症中的作用。
