Murphy D L, Mueller E A, Garrick N A, Aulakh C S
J Clin Psychiatry. 1986 Apr;47 Suppl:9-15.
To assess the status of the brain serotonergic system in relation to ongoing behavior, agents with predominant actions on serotonin synthesis, release, uptake, and receptor mechanisms are being evaluated. Abnormalities in the neuroendocrine responses to tryptophan, 5-hydroxytryptophan, fenfluramine, and m-chlorophenylpiperazine are under exploration in depressed patients. These agents are also being used to assess postulated changes in serotonin metabolism and serotonin receptor adaptation during longer term treatment with antidepressant drugs, lithium, and other psychoactive agents. Concurrent studies in rodent and nonhuman primate models are helping to validate these approaches to the exploration of the role of serotonin in psychiatric and neurologic disorders.
为了评估大脑血清素能系统与当前行为的关系，正在对主要作用于血清素合成、释放、摄取和受体机制的药物进行评估。正在研究抑郁症患者对色氨酸、5-羟色氨酸、芬氟拉明和间氯苯哌嗪的神经内分泌反应异常情况。这些药物也被用于评估在使用抗抑郁药、锂和其他精神活性药物进行长期治疗期间血清素代谢和血清素受体适应性的假定变化。在啮齿动物和非人类灵长类动物模型中进行的同步研究有助于验证这些探索血清素在精神和神经疾病中作用的方法。
