Kalafatis Chris, Modarres Mohammad Hadi, Apostolou Panos, Tabet Naji, Khaligh-Razavi Seyed-Mahdi
Cognetivity Neurosciences Ltd, London, United Kingdom.
South London & Maudsley NHS Foundation Trust, London, United Kingdom.
JMIR Res Protoc. 2022 Jan 27;11(1):e34475. doi: 10.2196/34475.
Existing primary care cognitive assessment tools are crude or time-consuming screening instruments which can only detect cognitive impairment when it is well established. Due to the COVID-19 pandemic, memory services have adapted to the new environment by moving to remote patient assessments to continue meeting service user demand. However, the remote use of cognitive assessments has been variable while there has been scant evaluation of the outcome of such a change in clinical practice. Emerging research in remote memory clinics has highlighted computerized cognitive tests, such as the Integrated Cognitive Assessment (ICA), as prominent candidates for adoption in clinical practice both during the pandemic and for post-COVID-19 implementation as part of health care innovation.
The aim of the Accelerating Dementia Pathway Technologies (ADePT) study is to develop a real-world evidence basis to support the adoption of ICA as an inexpensive screening tool for the detection of cognitive impairment to improve the efficiency of the dementia care pathway.
Patients who have been referred to a memory clinic by a general practitioner (GP) are recruited. Participants complete the ICA either at home or in the clinic along with medical history and usability questionnaires. The GP referral and ICA outcome are compared with the specialist diagnosis obtained at the memory clinic. The clinical outcomes as well as National Health Service reference costing data will be used to assess the potential health and economic benefits of the use of the ICA in the dementia diagnosis pathway.
The ADePT study was funded in January 2020 by Innovate UK (Project Number 105837). As of September 2021, 86 participants have been recruited in the study, with 23 participants also completing a retest visit. Initially, the study was designed for in-person visits at the memory clinic; however, in light of the COVID-19 pandemic, the study was amended to allow remote as well as face-to-face visits. The study was also expanded from a single site to 4 sites in the United Kingdom. We expect results to be published by the second quarter of 2022.
The ADePT study aims to improve the efficiency of the dementia care pathway at its very beginning and supports systems integration at the intersection between primary and secondary care. The introduction of a standardized, self-administered, digital assessment tool for the timely detection of neurodegeneration as part of a decision support system that can signpost accordingly can reduce unnecessary referrals, service backlog, and assessment variability.
ISRCTN 16596456; https://www.isrctn.com/ISRCTN16596456.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/34475.
现有的基层医疗认知评估工具要么粗糙,要么耗时,只是筛查工具,只有在认知障碍已经很严重时才能检测出来。由于新冠疫情,记忆服务通过转向远程患者评估来适应新环境,以继续满足服务用户的需求。然而,认知评估的远程使用情况各不相同,而对于这种临床实践变化的结果,几乎没有进行评估。远程记忆诊所的新研究强调了计算机化认知测试,如综合认知评估(ICA),是在疫情期间以及新冠疫情后作为医疗保健创新的一部分在临床实践中采用的突出候选工具。
加速痴呆症诊疗路径技术(ADePT)研究的目的是建立一个现实世界的证据基础,以支持采用ICA作为一种廉价的筛查工具来检测认知障碍,从而提高痴呆症诊疗路径的效率。
招募由全科医生(GP)转诊至记忆诊所的患者。参与者在家中或诊所完成ICA测试,同时填写病史和可用性问卷。将GP转诊情况和ICA测试结果与在记忆诊所获得的专科诊断进行比较。临床结果以及英国国家医疗服务体系参考成本数据将用于评估在痴呆症诊断路径中使用ICA的潜在健康和经济效益。
ADePT研究于2020年1月由英国创新署(项目编号105837)资助。截至2021年9月,该研究已招募了86名参与者,其中23名参与者还完成了重新测试访问。最初,该研究设计为在记忆诊所进行面对面访问;然而,鉴于新冠疫情,该研究进行了修订,允许远程访问以及面对面访问。该研究也从单一地点扩展到了英国的4个地点。我们预计结果将于2022年第二季度公布。
ADePT研究旨在从一开始就提高痴呆症诊疗路径的效率,并支持初级和二级医疗之间的系统整合。引入一种标准化的、可自行管理的数字评估工具,作为决策支持系统的一部分,用于及时检测神经退行性变,并能据此提供指引,可减少不必要的转诊、服务积压和评估差异。
ISRCTN 16596456;https://www.isrctn.com/ISRCTN16596456。
国际注册报告识别码(IRRID):DERR1-10.2196/34475。