以色列类风湿关节炎患者中HLA - DR4与胶原蛋白特异性抗体产生之间的关联。
Association between HLA-DR4 and production of collagen-specific antibodies in Israeli patients with rheumatoid arthritis.
作者信息
Tishler M, Brautbar C, Yaron M, Dayan M, Mozes E
出版信息
Isr J Med Sci. 1986 Nov;22(11):771-3.
PMID:3491807
Abstract
Antibodies to native human Type I + III collagen were measured by a radioimmunoassay in sera samples of 42 rheumatoid arthritis (RA) patients. Sixteen patients (38%) had significant antibody titers. Although the frequency of HLA-DR antigens of RA patients did not differ from that of the random Israeli population, there was a significant association (P less than 0.01) between the presence of collagen antibodies and HLA-DR4.
摘要
采用放射免疫分析法检测了42例类风湿性关节炎（RA）患者血清样本中针对天然人I型+III型胶原的抗体。16例患者（38%）抗体滴度显著。虽然RA患者的HLA-DR抗原频率与以色列随机人群无差异，但胶原抗体的存在与HLA-DR4之间存在显著关联（P<0.01）。
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