伴有外周关节炎的强直性脊柱炎中的免疫球蛋白同种异型Gm(1,2;21)
Immunoglobulin allotype Gm(1,2;21) in ankylosing spondylitis with peripheral arthritis.
作者信息
Mierau R, von Mühlen C A, Zarnowski H, Genth E, Hartl P W
机构信息
Rheumaforschungsinstitut, Rheumaklinik Aachen, FRG.
出版信息
Ann Rheum Dis. 1988 Nov;47(11):893-7. doi: 10.1136/ard.47.11.893.
Frequencies of immunoglobulin G (Gm) allotypes were determined in 240 patients with ankylosing spondylitis (AS). The uncommon phenotype Gm(1,2;21) was increased in frequency in 55 patients with AS and peripheral arthritis (14.5% v 3.5% of healthy blood donors; p less than 0.05). In 16 patients with arthritis only of wrist/hand or ankle/forefoot, or both, the Gm(1,2;21) frequency was even higher (31.3%; p less than 0.0005). Patients with AS negative for the HLA antigen B27 (n = 28) differed from the B27 positive patients (n = 205) with regard to the frequency of the Gm(1,2,3;5,21) phenotype (39.3% v 9.3%; p less than 0.0005). These findings support the notion of genetic heterogeneity among patients with AS.
测定了240例强直性脊柱炎（AS）患者免疫球蛋白G（Gm）同种异型的频率。55例患有AS和外周关节炎的患者中，罕见表型Gm(1,2;21)的频率增加（占健康献血者的14.5%，而健康献血者中为3.5%；p<0.05）。在仅患有腕部/手部或踝部/前足关节炎或两者皆有的16例患者中，Gm(1,2;21)频率甚至更高（31.3%；p<0.0005）。HLA抗原B27阴性的AS患者（n = 28）与B27阳性患者（n = 205）在Gm(1,2,3;5,21)表型频率方面存在差异（39.3%对9.3%；p<0.0005）。这些发现支持了AS患者存在遗传异质性的观点。
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