金雀异黄素对脂多糖诱导的子痫前期样大鼠的保护作用。
Protective effect of Fisetin on the lipopolysaccharide-induced preeclampsia-like rats.
机构信息
Department of Obstetrics and Gynecology, Shengli Oilfield Central Hospital, Dongying City, Shandong Province, China.
出版信息
Hypertens Pregnancy. 2022 Feb;41(1):23-30. doi: 10.1080/10641955.2021.2013874. Epub 2021 Dec 22.
OBJECTIVE
This article is aimed to investigate the function and underlying action mechanism of Fisetin in LPS-induced PE rats.
METHODS
LPS-induced PE-like rat model was established to explore the effects of Fisetin on PE in vivo.
RESULTS
Fisetin reduced hypertension, proteinuria, TNF-α, IL-6, IL-1β, MDA, and sFlt-1/PlGF ratio, but elevated the placental, fetal weight, GSH and SOD in PE rats. Moreover, Fisetin suppressed TLR4/NF-κB pathway, as well as promoting Nrf2/HO-1 pathway in placental tissues of PE rats.
CONCLUSIONS
Fisetin exerted protective role and modulated the activation of TLR4/NF-κB and Nrf2/HO-1 pathways in PE-like rat models.
目的
本文旨在研究非瑟酮在脂多糖诱导的 PE 大鼠中的作用及其潜在作用机制。
方法
建立 LPS 诱导的 PE 样大鼠模型，以探讨非瑟酮对 PE 的体内作用。
结果
非瑟酮降低了高血压、蛋白尿、TNF-α、IL-6、IL-1β、MDA 和 sFlt-1/PlGF 比值，但增加了 PE 大鼠的胎盘和胎儿体重、GSH 和 SOD。此外，非瑟酮抑制了 TLR4/NF-κB 通路，并促进了 PE 大鼠胎盘组织中的 Nrf2/HO-1 通路。
结论
非瑟酮在 PE 样大鼠模型中发挥了保护作用，并调节了 TLR4/NF-κB 和 Nrf2/HO-1 通路的激活。
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