Department of Otorhinolaryngology and Head and Neck Surgery, Chengdu Ren Pin Otorhinolaryngology Hospital, 51 Qinghua Road, Qingyang District, Chengdu, China.
Cell Mol Biol (Noisy-le-grand). 2021 Nov 25;67(3):125-128. doi: 10.14715/cmb/2021.67.3.17.
Nasal polyps are the most common benign nasal tumors that can lead to nasal obstruction and other annoying problems for the patient. Several hypotheses have been proposed as the basic mechanism of nasal polyps. In order to investigate one of the possible causes that can be a disorder in the regulation of systemic immune responses, the present study was designed to investigate the relationship between plasma cyclin-dependent kinase 5 (CDK5) levels and local immunoglobulin levels in patients with nasal polyps. A cross-section study was used to evaluate concentrations of local immunoglobulin levels (IgE, IgM, IgA, and IgG) on blood and polyp specimens from 60 patients with nasal polyps, and 60 control groups. Western Blot Analysis was done for CDK5 in plasma cells. IgA, IgG and IgE concentrations were significantly higher in polyp tissue specimens, but not in blood, of nasal polyp patients compared to the control group. Furthermore, plasma CDK5 levels were significantly higher in nasal polyp tissue compared with control. The difference in IgA, IgE and IgG expression between nasal polyp tissue and blood, supported by increased numbers of plasma cells, suggests a local production of these local immunoglobulins in nasal polyps in response to chronic antigens. Among local immunoglobulins, only there was a significant correlation between CDK5 with IgG (positive correlation) and IgE (negative correlation). The exact explanation for the relationship between plasma CDK5 and local immunoglobulins in nasal polyps needs further studies.
鼻息肉是最常见的良性鼻腔肿瘤，可导致患者出现鼻腔阻塞和其他令人烦恼的问题。已经提出了几种假说作为鼻息肉的基本机制。为了研究可能导致全身性免疫反应调节紊乱的原因之一，本研究旨在探讨鼻息肉患者血浆细胞周期蛋白依赖性激酶 5（CDK5）水平与局部免疫球蛋白水平之间的关系。采用横断面研究评估了 60 例鼻息肉患者和 60 例对照组的血液和息肉标本中局部免疫球蛋白水平（IgE、IgM、IgA 和 IgG）的浓度。对血浆细胞中的 CDK5 进行了 Western Blot 分析。与对照组相比，鼻息肉患者的息肉组织标本中 IgA、IgG 和 IgE 浓度显著升高，但血液中则不然。此外，鼻息肉组织中的血浆 CDK5 水平明显高于对照组。鼻息肉组织和血液之间的 IgA、IgE 和 IgG 表达差异，加上浆细胞数量的增加，提示这些局部免疫球蛋白在鼻息肉中对慢性抗原产生了局部产生。在局部免疫球蛋白中，只有 CDK5 与 IgG（正相关）和 IgE（负相关）之间存在显著相关性。血浆 CDK5 与鼻息肉中局部免疫球蛋白之间的关系的确切解释需要进一步研究。
