Matthews J B, Mason G I
Br J Oral Surg. 1983 Sep;21(3):192-7. doi: 10.1016/0007-117x(83)90041-0.
Ten cases of periapical granuloma were stained for igG, IgA, IgM, IgD and IgE by the unlabelled antibody peroxidase-antiperoxidase complex method to investigate the class distribution of plasma cells within the lesions. The results indicated that IgG containing plasma cells predominated in all lesions and that IgG, IgA, IgM, IgE and IgD cells represented 81.9, 11.4, 5.4, 1.1 and 0.2 per cent respectively, of the total positive cell population. All specimens contained IgE plasma cells in addition to many non-lymphoid cells showing membrane-like staining for IgE. The results suggest that in addition to tissue damage via local deposition of immune complexes IgE mediated immediate hypersensitivity reactions may have a role in pathogenesis.
采用未标记抗体过氧化物酶 - 抗过氧化物酶复合物法，对10例根尖周肉芽肿进行IgG、IgA、IgM、IgD和IgE染色，以研究病变内浆细胞的类别分布。结果表明，所有病变中含IgG的浆细胞占主导地位，IgG、IgA、IgM、IgE和IgD细胞分别占总阳性细胞群体的81.9%、11.4%、5.4%、1.1%和0.2%。所有标本除了许多对IgE呈膜样染色的非淋巴细胞外，还含有IgE浆细胞。结果提示，除了通过免疫复合物的局部沉积造成组织损伤外，IgE介导的速发型超敏反应可能在发病机制中起作用。
