2nd Department of Dermatology-Venereology, "Attikon" General University Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
State Clinic of Dermatology, Hospital for Skin and Venereal Diseases, Thessaloniki, Greece.
Eur J Dermatol. 2021 Dec 1;31(6):779-784. doi: 10.1684/ejd.2021.4178.
Basosquamous carcinoma (BSC) is a relatively rare type of neoplasm originating from basal cell carcinoma with features of squamous differentiation. BSC has an aggressive local behaviour with a tendency for recurrence and a less frequent metastatic potential The primary objective was to describe the dermatoscopic features of the tumour. Secondary goals were to detect the morphological features of the tumour along with patients' characteristics and to evaluate possible dermatoscopic and histopathological correlations Twenty-two patients with 25 BSCs were enrolled. All tumours were surgically excised and diagnosis was based on histopathology. Clinical and dermatoscopic images were evaluated by two investigators based on pre-defined criteria, and a statistical analysis was performed The median age of the patients was 78 years old (range: 52-88) and the male/female ratio was 2.14. All patients reported history of either occupational (50%) or recreational (50%) intensive sun exposure and 72.73% had signs of actinic keratosis. The most common anatomical site of the tumours was the head/neck area (72%). Clinically, nodular (64%), ulcerated (88%) and non-pigmented (76%) lesions prevailed. Dermatoscopically, 92% had prominent vasculature and monomorphous arborizing vessels with a diffuse arrangement, representing the most frequently observed type. Ulceration (88%), SCC dermatoscopic criteria (56%), white strands/blotches (56%) and features of pigmentation (40%) were also detected We suggest that the most common prototype of BSC is an ulcerated, facial nodule in elderly males with photo-damaged skin, dermatoscopically displaying combined features of mostly nodular BCC and, to a less extent, SCC.
基底鳞状细胞癌（BSC）是一种相对罕见的肿瘤，来源于具有鳞状分化特征的基底细胞癌。BSC 具有侵袭性的局部行为，倾向于复发，转移潜能较低。主要目的是描述肿瘤的皮肤镜特征。次要目标是检测肿瘤的形态特征以及患者的特征，并评估可能的皮肤镜和组织病理学相关性。 共纳入 22 例 25 例 BSC 患者。所有肿瘤均经手术切除，诊断基于组织病理学。两位研究者根据预定义标准评估临床和皮肤镜图像，并进行统计学分析。 患者的中位年龄为 78 岁（范围：52-88），男女比例为 2.14。所有患者均有职业（50%）或娱乐性（50%）高强度阳光暴露史，72.73%有光化性角化病迹象。肿瘤最常见的解剖部位是头颈部（72%）。临床上，结节状（64%）、溃疡性（88%）和非色素性（76%）病变占主导地位。皮肤镜下，92%有明显的血管和形态单一的树枝状血管，呈弥漫性排列，是最常见的观察类型。溃疡（88%）、SCC 皮肤镜标准（56%）、白色条纹/斑点（56%）和色素特征（40%）也被检测到。 我们认为 BSC 的最常见典型表现是在光损伤皮肤的老年男性面部出现溃疡性结节，皮肤镜下显示主要为结节性 BCC 的联合特征，在较小程度上也有 SCC 的特征。
