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埃及沙漠耳蕨和海兔蜗牛黏液的抗菌功效及其抗炎和伤口愈合功效的新方法。

Antimicrobial efficacy of Egyptian Eremina desertorum and Helix aspersa snail mucus with a novel approach to their anti-inflammatory and wound healing potencies.

机构信息

Botany Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.

Zoology Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.

出版信息

Sci Rep. 2021 Dec 21;11(1):24317. doi: 10.1038/s41598-021-03664-3.

DOI:10.1038/s41598-021-03664-3
PMID:34934098
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8692597/
Abstract

Snail mucus is composed of bioactive compounds thought to have different biological properties for the treatment of some skin problems. Although Helix aspersa mucus is used in several cosmetic products, a detailed characterization of Eremina desertorum mucus composition and its biological activities is still missing. Mucus extracts (MEs) from H. aspersa and E. desertorum were prepared and tested for their antimicrobial and anti-inflammatory activities with their potencies in wound healing. Also, chemical characterization was performed by GC-MS analysis. Results showed that ME of E. desertorum gave higher inhibitory activity against resistant strains related to burn wound infections compared to ME of H. aspersa. Additionally, it revealed a significant anti-inflammatory activity. Moreover, we found that ME of E. desertorum lacked cytotoxicity and was able to significantly induce cell proliferation and migration through up-regulation of TGF-β1 and VEGF gene expression. Our results suggested that MEs of E. desertorum have higher biological effects than H. aspersa, which are attributable to antimicrobial, anti-inflammatory activities, cell proliferation and pave the way for further investigating its potential effect as a human therapeutic agent.

摘要

蜗牛黏液由生物活性化合物组成，这些化合物被认为具有不同的生物学特性，可用于治疗一些皮肤问题。尽管海蜗牛黏液被用于多种化妆品中，但对沙漠蜗牛黏液的组成及其生物学活性的详细特征仍然知之甚少。本研究从海蜗牛和沙漠蜗牛中提取黏液提取物（MEs），并测试其对伤口愈合的抗菌和抗炎活性及其效力。此外，还通过 GC-MS 分析进行了化学表征。结果表明，与海蜗牛相比，沙漠蜗牛的 ME 对与烧伤感染有关的耐药菌株具有更高的抑制活性。此外，它还显示出显著的抗炎活性。此外，我们发现沙漠蜗牛的 ME 没有细胞毒性，能够通过上调 TGF-β1 和 VEGF 基因表达显著诱导细胞增殖和迁移。我们的研究结果表明，沙漠蜗牛的 MEs 比海蜗牛具有更高的生物学效应，这归因于其抗菌、抗炎活性、细胞增殖，为进一步研究其作为人类治疗剂的潜在作用铺平了道路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1502/8692597/b3b039f7fe0e/41598_2021_3664_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1502/8692597/7bd45c1ee738/41598_2021_3664_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1502/8692597/4bd021a9ca84/41598_2021_3664_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1502/8692597/ab52c42b2b73/41598_2021_3664_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1502/8692597/60f0ef760fec/41598_2021_3664_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1502/8692597/b3b039f7fe0e/41598_2021_3664_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1502/8692597/7bd45c1ee738/41598_2021_3664_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1502/8692597/4bd021a9ca84/41598_2021_3664_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1502/8692597/ab52c42b2b73/41598_2021_3664_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1502/8692597/60f0ef760fec/41598_2021_3664_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1502/8692597/b3b039f7fe0e/41598_2021_3664_Fig5_HTML.jpg

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